Featured Research

from universities, journals, and other organizations

Simplified Therapy To Prevent TB Proven Effective In Developing Countries

Date:
March 19, 1998
Source:
Johns Hopkins School Of Public Health
Summary:
People with HIV in developing countries are far more likely to contract tuberculosis than those without HIV. Now researchers at the Johns Hopkins School of Public have found that a simplified regimen of twice-weekly doses of isoniazid preventive therapy administered for six months or rifampicin and pyrazinamide administered for only two months provided similar overall protection against tuberculosis in HIV-infected, PPD-positive adults.

People with HIV in developing countries are far more likely to contract tuberculosis than those without HIV. Although drugs to help prevent TB are available, the normal course of treatment is 12 months, making it difficult for people to comply with treatment especially in countries where access to care is a problem as is monitoring medication. In most developing countries preventive therapy for high risk individuals is not given because of limited resources. Researchers at the Johns Hopkins School of Public have found that a simplified regimen of twice-weekly doses of isoniazid preventive therapy administered for six months or rifampicin and pyrazinamide administered for only two months provided similar overall protection against tuberculosis in HIV-infected, PPD-positive adults.

Related Articles


The study was published in the March 14, 1998 issue of Lancet. Lead author Neal Halsey, MD, professor, International Health, said, "We need to look for innovative and practical ways to prevent TB in developing countries. The current strategy of emphasizing, early diagnosis and treatment of active cases can be improved upon with minimal added resources."

The study looked at 750 participants who were randomly assigned to receive either six months of isoniazid or two months of rifampicin and pyrazinamide given just twice per week. All participants were HIV positive and had a positive purified-protein derivative (PPD) skin test but no signs of active disease. Both regimens proved to be effective in preventing active TB. However, compliance with treatment was higher for those who received the shorter course of treatment. Adherence was strongly associated with duration of treatment. Co-author Richard Chaisson, MD, associate professor, International Health said, "This is great leap forward in finding a way to prevent TB in a lot of people who previously would not have been able to receive appropriate preventive measures."

The results of this study were presented to an expert panel assembled last month by UNAIDS and the World Health Organization that considered treatments to prevent tuberculosis in people with HIV. The two regimens used by the Hopkins researchers will be the centerpiece of new global recommendations, expected to be issued later this year.


Story Source:

The above story is based on materials provided by Johns Hopkins School Of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins School Of Public Health. "Simplified Therapy To Prevent TB Proven Effective In Developing Countries." ScienceDaily. ScienceDaily, 19 March 1998. <www.sciencedaily.com/releases/1998/03/980319072638.htm>.
Johns Hopkins School Of Public Health. (1998, March 19). Simplified Therapy To Prevent TB Proven Effective In Developing Countries. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/1998/03/980319072638.htm
Johns Hopkins School Of Public Health. "Simplified Therapy To Prevent TB Proven Effective In Developing Countries." ScienceDaily. www.sciencedaily.com/releases/1998/03/980319072638.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins