Featured Research

from universities, journals, and other organizations

'Eat Your Vegetables,' Says Researcher -- Cancer Cell Division Is Blocked By Chemical In Carrots, Cornell Biologists Show

Date:
April 14, 1998
Source:
Cornell University
Summary:
A common chemical derivative of vegetables has been used by Cornell University researchers studying leukemia to block the uncontrolled cell division that leads to cancer.

ITHACA, N.Y. -- A common chemical derivative of vegetables has beenused by Cornell University researchers studying leukemia to block theuncontrolled cell division that leads to cancer.

The chemical is retinoic acid, a product of vitamin A, which thebody manufactures from carotenes, the compounds found in a wide assortmentof yellow-orange vegetables and fruits, from carrots and sweet potatoes topumpkins and apricots.

Retinoic acid reverses the growth-promoting effects of oncogenes,the mutated genetic material that induces cancer, says Andrew Yen, aprofessor of pathology and director of one of the Cancer BiologyLaboratories in Cornell University's College of Veterinary Medicine.

The finding, which to date has been restricted to the test-tubelevel, could lead to enhanced therapies for those cancers, includingleukemia, that seem to respond to retinoic acid. The research alsohighlights the cancer-prevention role of carotenes.

"This is one more reason," Yen says, "to listen to your mother andeat your vegetables."

Yen reported the cell growth-arresting function of retinoic acidMarch 30 in New Orleans at the annual meeting of the American Associationfor Cancer Research. More details are in an article prepared for theassociation's journal, "Cancer Research". Previously, progress by Yen'slaboratory in explaining the role of retinoic acid was reported in a seriesof articles in several journals, including "Blood", "European Journal ofCell Biology" and "Experimental Cell Research.

" Retinoic acid is a metabolic product of retinol, the active form ofvitamin A. The compound had been shown by other researchers to regulatenormal cell growth and differentiation. Yen's latest results -- usingtransforming proteins to switch on proto-oncogenes, the precursors tooncogenes -- demonstrate how retinoic acid can use the samechemical-signalling cascades that cause cell growth instead to arrestgrowth.

"Retinoic acid can reverse the defect in growth control that wascaused by the viral agent and result in cell-growth arrest," Yen says,describing his experiments with cell cultures. "Now we need a deeperunderstanding of how retinoic acid causes these changes -- and exactlywhich molecules are affected by retinoic acid. In my dreams there is asingle effector, but it's more likely there are several."

Ongoing studies in the Yen laboratory, supported in part by theNational Cancer Institute and the U.S. Department of Agriculture's Programin Human Nutrition, aim to explain exactly how retinoic acid works ononcogenes and whether other, related compounds would be more effective inchemotherapy. As a result, oncologists might be able to fine-tune thechemotherapy cocktails given not only to leukemia patients but also topatients with other types of cancer, Yen suggests.

"In the meantime," he says, "I think we're adding evidence that anadequate supply of carotene in the diet is obviously beneficial for anyonewho wishes to stay healthy and avoid cancer."


Story Source:

The above story is based on materials provided by Cornell University. Note: Materials may be edited for content and length.


Cite This Page:

Cornell University. "'Eat Your Vegetables,' Says Researcher -- Cancer Cell Division Is Blocked By Chemical In Carrots, Cornell Biologists Show." ScienceDaily. ScienceDaily, 14 April 1998. <www.sciencedaily.com/releases/1998/04/980414081653.htm>.
Cornell University. (1998, April 14). 'Eat Your Vegetables,' Says Researcher -- Cancer Cell Division Is Blocked By Chemical In Carrots, Cornell Biologists Show. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/1998/04/980414081653.htm
Cornell University. "'Eat Your Vegetables,' Says Researcher -- Cancer Cell Division Is Blocked By Chemical In Carrots, Cornell Biologists Show." ScienceDaily. www.sciencedaily.com/releases/1998/04/980414081653.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins