Featured Research

from universities, journals, and other organizations

Researchers Identify Protein Critical To Urine Concentration

Date:
April 21, 1998
Source:
University Of California, San Francisco
Summary:
UC San Francisco researchers have identified a protein in mice that is essential for enabling the kidneys to form concentrated urine, a process that is critical for preventing severe dehydration of the body during times of water deprivation.

SAN FRANCISCO -- UC San Francisco researchers have identified a protein in mice that is essential for enabling the kidneys to form concentrated urine, a process that is critical for preventing severe dehydration of the body during times of water deprivation.

The finding, which will be presented on Sunday, April 19, at the Federation of the American Society of Experimental Biology (FASEB) meeting here, provides fundamental information about how the urine concentrating mechanism works in the kidney.

It also has potential clinical implications for the treatment of diseases associated with fluid retention, or refractory edema, including congestive heart failure and cirrhosis, said the researchers.

"If we could inhibit the water channel with drugs," says A.S. Verkman, MD, PhD, UCSF professor of medicine and physiology, "then problems of fluid retention could be effectively treated where conventional diuretics don't work."

The study was published recently in The Journal of Biological Chemistry (Feb. 20).

Normally, the body produces an unconcentrated urine. However, during times of water deprivation, it must conserve water, and one of the key ways of doing so is to concentrate the urine.

In the UCSF study, the researchers "knocked out," or removed, the gene for the water transporting protein, known as aquaporin 1, which is found widely in animals. They then deprived the mice of water. Within 36 hours, these mice had become severely dehydrated and lethargic, had lost substantial weight, and nearly died. Notably, nearly every mouse was resuscitated by oral water administration. In contrast, mice without the gene deletion continued to thrive, displaying only a moderate weight loss.

"This study," said Verkman, "demonstrates that the missing protein is essential for the mouse kidney to form a concentrated urine."

Moreover, he said, "the dramatic reaction to the deletion of the protein in mice raises the possibility that other mammalian aquaporins have important physiological functions.

"Deletion of each remaining aquaporin in mice is likely to be informative," he says, "as might the screening for aquaporin mutations in genetic diseases associated with abnormalities of fluid balance."


Story Source:

The above story is based on materials provided by University Of California, San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, San Francisco. "Researchers Identify Protein Critical To Urine Concentration." ScienceDaily. ScienceDaily, 21 April 1998. <www.sciencedaily.com/releases/1998/04/980421080853.htm>.
University Of California, San Francisco. (1998, April 21). Researchers Identify Protein Critical To Urine Concentration. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/1998/04/980421080853.htm
University Of California, San Francisco. "Researchers Identify Protein Critical To Urine Concentration." ScienceDaily. www.sciencedaily.com/releases/1998/04/980421080853.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins