Featured Research

from universities, journals, and other organizations

Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma

Date:
May 11, 1998
Source:
National Jewish Medical And Research Center
Summary:
Researchers at National Jewish Medical and Research Center are performing clinical trials and basic science research on laboratory-made IL-4 receptors, which have been shown to successfully bind to IL-4 in humans.

DENVER--Researchers at National Jewish Medical and Research Center are performing clinical trials and basic science research on laboratory-made IL-4 receptors, which have been shown to successfully bind to IL-4 in humans. National Jewish researchers are currently testing an inhaled form of the IL-4 receptor.

Related Articles


When an allergen enters the body it stimulates production of the gene IL-4. When IL-4 attaches to an IL-4 receptor, found on cells in the body, this contact produces IgE. IgE causes the immune system to respond in the form of a runny nose, watery eyes and other symptoms. In many people with asthma, the IL-4 receptor is highly sensitive, which causes allergic asthma.

"This goes at the source of allergies. We're not treating symptoms, we're eliminating disease," said Larry Borish, M.D., a physician researcher in the National Jewish Department of Medicine.

The inhaled IL-4 receptor doesn't stop the body's production of IL-4. Instead the inhaled IL-4 receptor "soaks up" the body's available IL-4 by chemically binding to it before it reaches and activates the IL-4 receptor on the surface of the cell. "It is like a sponge," Dr. Borish said.

In early clinical trials in people with asthma, the artificial IL-4 receptor has had no side effects, remained in the body for 8 days and kept allergy symptoms from occurring. In addition, the use of an inhaled IL-4 receptor reduced the use of other asthma medications, such as beta-agonists and inhaled corticosteroids.

The latest clinical trial using inhaled IL-4 receptors currently is accepting new patients. Patients will receive one dose of IL-4 every week for 12 weeks. Patients must live in the Denver metropolitan area. For information on enrolling in the study, call (303) 398-1911.

Artificial IL-4 receptors could be widely available as a treatment option in two to three years.

National Jewish researchers have done many of the preliminary studies on IL-4 showing that IL-4 is a major gene that causes allergies and that mice without IL-4 genes don't get asthma.


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma." ScienceDaily. ScienceDaily, 11 May 1998. <www.sciencedaily.com/releases/1998/05/980508101131.htm>.
National Jewish Medical And Research Center. (1998, May 11). Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/1998/05/980508101131.htm
National Jewish Medical And Research Center. "Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma." ScienceDaily. www.sciencedaily.com/releases/1998/05/980508101131.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins