Featured Research

from universities, journals, and other organizations

Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma

Date:
May 11, 1998
Source:
National Jewish Medical And Research Center
Summary:
Researchers at National Jewish Medical and Research Center are performing clinical trials and basic science research on laboratory-made IL-4 receptors, which have been shown to successfully bind to IL-4 in humans.

DENVER--Researchers at National Jewish Medical and Research Center are performing clinical trials and basic science research on laboratory-made IL-4 receptors, which have been shown to successfully bind to IL-4 in humans. National Jewish researchers are currently testing an inhaled form of the IL-4 receptor.

When an allergen enters the body it stimulates production of the gene IL-4. When IL-4 attaches to an IL-4 receptor, found on cells in the body, this contact produces IgE. IgE causes the immune system to respond in the form of a runny nose, watery eyes and other symptoms. In many people with asthma, the IL-4 receptor is highly sensitive, which causes allergic asthma.

"This goes at the source of allergies. We're not treating symptoms, we're eliminating disease," said Larry Borish, M.D., a physician researcher in the National Jewish Department of Medicine.

The inhaled IL-4 receptor doesn't stop the body's production of IL-4. Instead the inhaled IL-4 receptor "soaks up" the body's available IL-4 by chemically binding to it before it reaches and activates the IL-4 receptor on the surface of the cell. "It is like a sponge," Dr. Borish said.

In early clinical trials in people with asthma, the artificial IL-4 receptor has had no side effects, remained in the body for 8 days and kept allergy symptoms from occurring. In addition, the use of an inhaled IL-4 receptor reduced the use of other asthma medications, such as beta-agonists and inhaled corticosteroids.

The latest clinical trial using inhaled IL-4 receptors currently is accepting new patients. Patients will receive one dose of IL-4 every week for 12 weeks. Patients must live in the Denver metropolitan area. For information on enrolling in the study, call (303) 398-1911.

Artificial IL-4 receptors could be widely available as a treatment option in two to three years.

National Jewish researchers have done many of the preliminary studies on IL-4 showing that IL-4 is a major gene that causes allergies and that mice without IL-4 genes don't get asthma.


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma." ScienceDaily. ScienceDaily, 11 May 1998. <www.sciencedaily.com/releases/1998/05/980508101131.htm>.
National Jewish Medical And Research Center. (1998, May 11). Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/1998/05/980508101131.htm
National Jewish Medical And Research Center. "Artificial Il-4 Receptor Could Stop Allergies, Help People With Allergic Asthma." ScienceDaily. www.sciencedaily.com/releases/1998/05/980508101131.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins