Featured Research

from universities, journals, and other organizations

Some AIDS Patients May Show Resistance To Sulfa Drugs

Date:
May 12, 1998
Source:
University Of Michigan
Summary:
Researchers in the University of Michigan HIV/AIDS Program and the U-M School of Public Health have discovered mutations in the genetic make-up of a type of pneumonia that is the most common severe opportunistic infection in people with AIDS.

ANN ARBOR---Researchers in the University of Michigan HIV/AIDS Program and the U-M School of Public Health have discovered mutations in the genetic make-up of a type of pneumonia that is the most common severe opportunistic infection in people with AIDS.

The results are reported in the May 1998 issue of the journal AIDS.

The genetic mutations occurred in significantly larger numbers among patients who were taking medication that has proven very successful in preventing pneumocystis carinii pneumonia. The study's authors believe this could signal the emergence of resistance to these medications---called sulfa drugs. Sulfa has proven to be the most effective and widely used drug for preventing and treating pneumocystis, but it does fail in some cases.

"The importance of this study is that it documents mutations in pneumocystis in HIV/AIDS patients," says Powell Kazanjian, M.D., associate professor of internal medicine and director of the HIV/AIDS Program in the U-M Health System. "It is possible that the mutations may lead to resistance to sulfa in pneumocystis."

Kazanjian conducted the study in collaboration with Steven Meshnick, Ph.D., M.D., professor of epidemiology, U-M School of Public Health.

Researchers extracted DNA from the medical specimens of 27 patients who had been treated for pneumocystis between January 1991 and April 1997. Twenty of the patients had AIDS and the other seven were non-HIV-infected patients with compromised immune systems. Samples were obtained from the U-M, Indiana University Medical Center and Ann Arbor Veterans Administration Hospital.

Investigators examined the pneumocystis gene that is targeted by sulfa drugs and found a significantly higher incidence of mutation in patients who were taking sulfa drugs (71 percent) compared with those who weren't (15 percent). All of the mutations occurred in patients with AIDS.

The mutations occurred at two amino-acid positions. Kazanjian and Meshnick believe these two mutation points may be involved in sulfa binding. The same types of genetic mutations have been previously documented to be associated with resistance to sulfa in certain strains of meningitis, streptococcus and malaria.

The study authors say it was not possible to determine what caused the mutations or if the mutations represented actual resistance. Kazanjian and Meshnick are currently conducting a larger study to further investigate these findings. Follow-up studies to determine if resistance is occurring, Kazanjian says, will examine what effect larger sulfa doses have on these mutations, what is causing the mutations and exactly how the mutations might interfere with sulfa.

Kazanjian and Meshnick say study results indicate that the mutations are a recent occurrence. The research team found no evidence of mutations in any of the samples prior to 1995.

Sulfa targets pneumocystis at the genetic level, interrupting the synthesis of folic acid, which is responsible for cell division.


Story Source:

The above story is based on materials provided by University Of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University Of Michigan. "Some AIDS Patients May Show Resistance To Sulfa Drugs." ScienceDaily. ScienceDaily, 12 May 1998. <www.sciencedaily.com/releases/1998/05/980512080654.htm>.
University Of Michigan. (1998, May 12). Some AIDS Patients May Show Resistance To Sulfa Drugs. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/1998/05/980512080654.htm
University Of Michigan. "Some AIDS Patients May Show Resistance To Sulfa Drugs." ScienceDaily. www.sciencedaily.com/releases/1998/05/980512080654.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins