Featured Research

from universities, journals, and other organizations

Some AIDS Patients May Show Resistance To Sulfa Drugs

Date:
May 12, 1998
Source:
University Of Michigan
Summary:
Researchers in the University of Michigan HIV/AIDS Program and the U-M School of Public Health have discovered mutations in the genetic make-up of a type of pneumonia that is the most common severe opportunistic infection in people with AIDS.

ANN ARBOR---Researchers in the University of Michigan HIV/AIDS Program and the U-M School of Public Health have discovered mutations in the genetic make-up of a type of pneumonia that is the most common severe opportunistic infection in people with AIDS.

Related Articles


The results are reported in the May 1998 issue of the journal AIDS.

The genetic mutations occurred in significantly larger numbers among patients who were taking medication that has proven very successful in preventing pneumocystis carinii pneumonia. The study's authors believe this could signal the emergence of resistance to these medications---called sulfa drugs. Sulfa has proven to be the most effective and widely used drug for preventing and treating pneumocystis, but it does fail in some cases.

"The importance of this study is that it documents mutations in pneumocystis in HIV/AIDS patients," says Powell Kazanjian, M.D., associate professor of internal medicine and director of the HIV/AIDS Program in the U-M Health System. "It is possible that the mutations may lead to resistance to sulfa in pneumocystis."

Kazanjian conducted the study in collaboration with Steven Meshnick, Ph.D., M.D., professor of epidemiology, U-M School of Public Health.

Researchers extracted DNA from the medical specimens of 27 patients who had been treated for pneumocystis between January 1991 and April 1997. Twenty of the patients had AIDS and the other seven were non-HIV-infected patients with compromised immune systems. Samples were obtained from the U-M, Indiana University Medical Center and Ann Arbor Veterans Administration Hospital.

Investigators examined the pneumocystis gene that is targeted by sulfa drugs and found a significantly higher incidence of mutation in patients who were taking sulfa drugs (71 percent) compared with those who weren't (15 percent). All of the mutations occurred in patients with AIDS.

The mutations occurred at two amino-acid positions. Kazanjian and Meshnick believe these two mutation points may be involved in sulfa binding. The same types of genetic mutations have been previously documented to be associated with resistance to sulfa in certain strains of meningitis, streptococcus and malaria.

The study authors say it was not possible to determine what caused the mutations or if the mutations represented actual resistance. Kazanjian and Meshnick are currently conducting a larger study to further investigate these findings. Follow-up studies to determine if resistance is occurring, Kazanjian says, will examine what effect larger sulfa doses have on these mutations, what is causing the mutations and exactly how the mutations might interfere with sulfa.

Kazanjian and Meshnick say study results indicate that the mutations are a recent occurrence. The research team found no evidence of mutations in any of the samples prior to 1995.

Sulfa targets pneumocystis at the genetic level, interrupting the synthesis of folic acid, which is responsible for cell division.


Story Source:

The above story is based on materials provided by University Of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University Of Michigan. "Some AIDS Patients May Show Resistance To Sulfa Drugs." ScienceDaily. ScienceDaily, 12 May 1998. <www.sciencedaily.com/releases/1998/05/980512080654.htm>.
University Of Michigan. (1998, May 12). Some AIDS Patients May Show Resistance To Sulfa Drugs. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/1998/05/980512080654.htm
University Of Michigan. "Some AIDS Patients May Show Resistance To Sulfa Drugs." ScienceDaily. www.sciencedaily.com/releases/1998/05/980512080654.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins