Featured Research

from universities, journals, and other organizations

Researchers Identify A Gene That Causes Juvenile Polyposis

Date:
May 20, 1998
Source:
University Of Iowa
Summary:
A gene causing familial juvenile polyposis (FJP), a disorder that causes the growth of polyps in the colon or upper gastrointestinal tract, has been identified.

IOWA CITY, Iowa -- A gene causing familial juvenile polyposis (FJP), a disorder that causes the growth of polyps in the colon or upper gastrointestinal tract, has been identified.

Dr. James Howe, University of Iowa assistant professor of surgery, led an international team that identified a mutated tumor suppressor gene found in families with the disorder from Iowa, Mississippi, Finland and England. The finding is published in the May 15 issue of the journal Science. FJP affects about 1 in 100,000 people, Howe says -- usually with the onset of symptoms within the first two decades of life. The most common symptom is rectal bleeding.

The condition was at first thought to be benign, however, in a 1975 study, University of Iowa College of Medicine researchers demonstrated that people with FJP had a high risk of developing gastrointestinal cancer. If an individual has a parent or sibling with FJP, they have a 50 percent chance of also having the disease plus an increased risk of cancer.

While identification of a gene responsible for FJP will help to identify carriers of the abnormal gene and facilitate the screening of family members, the implications of this finding may reach beyond FJP.

"FJP is a relatively rare disease. However, 75 percent of colon cancer cases have chromosomal losses from this region of the genome," Howe says. "Understanding this gene may increase our understanding of colorectal cancer in general, and could provide insights into its diagnosis and treatment."

It took less than two years for Howe and his colleagues to pinpoint the errant gene. Howe credits the Human Genome Project for acceleration the process of gene identification, particularly for making available good markers to help determine the chromosome where genes are located. The group was able to identify the chromosome using linkage studies a year after beginning the project. The gene, SMAD4/DPC4, was originally identified and mapped in 1996 by researchers at Johns Hopkins University. Deletions of this gene have been described in 50 percent of pancreatic cancers and in 15 percent of colorectal cancers. Howe's research is a work in progress.

"We know that this gene causes FJP in a subset of families, but we also know that it doesn't cause it in all families," Howe says. "The incidence may be as low as 20 percent or as high as 55 percent. There are clearly other genes which may cause FJP."

The next phase of this study is to determine if SMAD4/DPC4 is mutated in members of different families and to look at other genes related to SMAD4/DPC4 to determine whether mutations in those genes produce similar disorders.


Story Source:

The above story is based on materials provided by University Of Iowa. Note: Materials may be edited for content and length.


Cite This Page:

University Of Iowa. "Researchers Identify A Gene That Causes Juvenile Polyposis." ScienceDaily. ScienceDaily, 20 May 1998. <www.sciencedaily.com/releases/1998/05/980520081348.htm>.
University Of Iowa. (1998, May 20). Researchers Identify A Gene That Causes Juvenile Polyposis. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/1998/05/980520081348.htm
University Of Iowa. "Researchers Identify A Gene That Causes Juvenile Polyposis." ScienceDaily. www.sciencedaily.com/releases/1998/05/980520081348.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins