Featured Research

from universities, journals, and other organizations

Ulcer Drug Linked To Birth Defects

Date:
June 30, 1998
Source:
The Hospital For Sick Children
Summary:
Researchers at Toronto's Hospital for Sick Children and several hospitals in Brazil have determined that a drug commonly used for the treatment and prevention of ulcers causes a significant birth defect if taken during pregnancy. The drug, misoprostol, joins an international list of approximately 24 medications proven to cause birth defects.

TORONTO, Ontario, Canada--Researchers at Toronto's Hospital for Sick Children (HSC) and several hospitals in Brazil have determined that a drug commonly used for the treatment and prevention of ulcers causes a significant birth defect if taken during pregnancy. The drug, misoprostol, joins an international list of approximately 24 medications proven to cause birth defects. The research is reported in the June 25 issue of the New England Journal of Medicine.

"Our research determined that misoprostol causes a congenital facial paralysis known as Mobius syndrome," explains lead researcher Anne Pastuszak, MSc, of HSC's Motherisk program and director of the University of Toronto Fetal Diagnosis and Treatment Centre. "The drug is not recommended for use in pregnancy because it may stimulate uterine contractions and cause vaginal bleeding and miscarriage."

It is these side effects that prompt some Brazilian women to take misoprostol--which is available over the counter in Brazil but only by prescription in Canada--in an attempt to terminate their pregnancy. However, the drug does not always cause miscarriage and children born to mothers who have taken misoprostol are more likely to have Mobius syndrome than women who have not taken the drug.

The case control study compared the frequency of misoprostol use during the first trimester between mothers of 96 Brazilian infants diagnosed with Mobius syndrome and mothers of 96 infants with neural tube defects. Among the mothers of infants with Mobius syndrome, 47 (49 per cent) had taken misoprostol during pregnancy compared with just three (three percent) of the mothers from the other group.

Mobius syndrome is a rare disorder that is characterized by lifetime facial paralysis. People with Mobius syndrome can't smile or frown, and they often can't blink or move their eyes from side to side. Mobius syndrome results from the under-development of two important cranial nerves, however, the precise cause is unknown.

This research was funded by The Hospital for Sick Children Foundation and the Brazilian Research Council.


Story Source:

The above story is based on materials provided by The Hospital For Sick Children. Note: Materials may be edited for content and length.


Cite This Page:

The Hospital For Sick Children. "Ulcer Drug Linked To Birth Defects." ScienceDaily. ScienceDaily, 30 June 1998. <www.sciencedaily.com/releases/1998/06/980630081514.htm>.
The Hospital For Sick Children. (1998, June 30). Ulcer Drug Linked To Birth Defects. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/1998/06/980630081514.htm
The Hospital For Sick Children. "Ulcer Drug Linked To Birth Defects." ScienceDaily. www.sciencedaily.com/releases/1998/06/980630081514.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins