Featured Research

from universities, journals, and other organizations

Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis

Date:
September 16, 1998
Source:
University Of Washington
Summary:
A recently completed study shows that calcitonin-salmon nasal spray reduced by 36 percent the incidence of new spinal fractures in postmenopausal women with osteoporosis.

A recently completed study shows that calcitonin-salmon nasal spray reduced by 36 percent the incidence of new spinal fractures in postmenopausal women with osteoporosis.

Dr. Charles Chesnut, professor of radiology and medicine at the University of Washington in Seattle, presented results of the study at the European Congress on Osteoporosis in Berlin on Sept. 14.

Calcitonin-salmon is currently indicated for treatment of osteoporosis in women who are more than five years past menopause and for whom estrogen replacement therapy is not an option.

More than 1,200 women who had already experienced at least one spinal fracture took part in the five-year trial, called the Prevent Recurrence of Osteoporotic Fractures (PROOF) Study, conducted at 42 sites in the United States and five sites in the United Kingdom. The study was funded by Novartis Pharmaceuticals Corporation, which markets the drug in the U.S. as Miacalcin Nasal Spray.

Women taking calcitonin-salmon nasal spray (one spray of 200 IUs per day) experienced 36 percent fewer new spinal fractures than those taking placebo. All participants took supplemental calcium and vitamin D. There was no increase in side effects overall compared with women receiving placebo.

"The study results should provide encouragement to the millions of women who have suffered from the debilitating effects of a spinal fracture," said Chesnut, principal investigator on the study. "The data confirm the ability of a medicine known to be safe to reduce spinal fractures."

Based on the study results, Novartis filed a supplemental new-drug application with the U.S. Food and Drug Administration in July 1998, for use of calcitonin-salmon nasal spray for prevention of spinal fractures.

Spinal fractures (compressed vertebrae) are the most common complication of osteoporosis. Of the 1.5 million osteoporotic fractures that occur annually in the U.S., 700,000 occur in the spine, according to the National Osteoporosis Foundation.

Spinal fractures result in such irreversible changes as loss of height and stooped posture. However, fractures of the spine and a shrinking frame are not inevitable consequences of aging.

Clinical trials have shown that side effects from calcitonin-salmon are comparable to placebo. Most commonly reported side effects are nasal irritation such as runny nose, crusting and nosebleed, back and/or joint pain, and headache. Because calcitonin is a protein, the possibility of a systemic allergic reaction exists.


Story Source:

The above story is based on materials provided by University Of Washington. Note: Materials may be edited for content and length.


Cite This Page:

University Of Washington. "Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis." ScienceDaily. ScienceDaily, 16 September 1998. <www.sciencedaily.com/releases/1998/09/980916073652.htm>.
University Of Washington. (1998, September 16). Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/1998/09/980916073652.htm
University Of Washington. "Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis." ScienceDaily. www.sciencedaily.com/releases/1998/09/980916073652.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins