Featured Research

from universities, journals, and other organizations

Jefferson Scientists Suppress Tumor Growth In Animals, Aiming At Gene Therapy

Date:
October 7, 1998
Source:
Thomas Jefferson University
Summary:
Scientists at Jefferson Medical College believe they have taken the next step toward gene therapy trials for lung cancer.

Scientists at Jefferson Medical College believe they have taken the next step toward gene therapy trials for lung cancer.

They have demonstrated for the first time in laboratory animals that a normally protective anticancer gene, pRb2/p130, can actually block tumors from growing. A damaged version of the gene, termed a "tumor suppressor," has been implicated in several cancers, such as lung, breast and endometrial.

Previous test tube experiments had proven that tumors wouldn't grow when the gene--and its protein product--were present. But "curing cancer" in the test tube is one thing. Now that they've found the gene stops cancer formation in an animal model, the next step would be to understand how the gene and its protein actually work.

Eventually, the scientists, led by Antonio Giordano, M.D., Ph.D., associate professor of pathology, anatomy and cell biology at Thomas Jefferson University in Philadelphia, would like to develop a gene therapy procedure against Rb2 to treat cancer.

Verifying Rb2's function, Dr. Giordano says, "shows the complexity of cancer.

"It's clear that Rb2 is one of a small number of tumor suppressor genes that play important roles in cancer," he says. "We know now that Rb2 can be therapeutically powerful. Understanding how they work is key to solving the puzzle of cancer formation. We think that Rb2 is used in combination with other tumor suppressor genes."

Dr. Giordano and his colleagues at Allegheny University of the Health Sciences and the University of Naples report their results October 7 in the Journal of the National Cancer Institute.

"The importance of this work is that it's the first time we have shown that the tumor suppressor, pRb2/p130, is able to suppress tumor growth in mice," says Dr. Giordano. "In the past, we only showed that Rb2 could suppress cancer cell lines from growing. Now we find it dramatically does so on mice. It's a very exciting study to show this dramatically inhibiting cancer cell growth."

While the biochemical pathway of tumor suppression isn't completely understood, "with this discovery, we have another tool," Dr. Giordano says. "It's known that Rb2 controls vital cell processes, including apoptosis (programmed cell death).

"Gene therapy would target cancers in which we know this gene is involved--lung, mesothelioma, endometrial, breast, glioblastoma, lymphoma," he says. "We are working on a delivery system for every cancer."


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Jefferson Scientists Suppress Tumor Growth In Animals, Aiming At Gene Therapy." ScienceDaily. ScienceDaily, 7 October 1998. <www.sciencedaily.com/releases/1998/10/981007071833.htm>.
Thomas Jefferson University. (1998, October 7). Jefferson Scientists Suppress Tumor Growth In Animals, Aiming At Gene Therapy. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/1998/10/981007071833.htm
Thomas Jefferson University. "Jefferson Scientists Suppress Tumor Growth In Animals, Aiming At Gene Therapy." ScienceDaily. www.sciencedaily.com/releases/1998/10/981007071833.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins