Featured Research

from universities, journals, and other organizations

UNC-CH Studies Show Medicine Can Reverse Osteoporosis From Transplants, Cystic Fibrosis

Date:
October 20, 1998
Source:
University Of North Carolina At Chapel Hill
Summary:
Studies of a drug known as Pamidronate indicate that the drug is highly effective in partially reversing the bone weakening known as osteoporosis due to drugs taken after various transplants, including lung transplants in cystic fibrosis patients.

CHAPEL HILL - Studies of a drug known as Pamidronate indicate that the drug is highly effective in partially reversing the bone weakening known as osteoporosis due to drugs taken after various transplants, including lung transplants in cystic fibrosis patients.

The studies, described at the 12th Annual North American Cystic Fibrosis Conference in Montreal that ended Sunday (Oct. 18), found that patients treated with Pamidronate experienced about a 10 percent reversal of bone loss caused by immuno-suppressant drugs.

Drs. Robert M. Aris, assistant professor of medicine; David Ontjes, professor of medicine; and Gayle E. Lester, research associate professor of orthopaedics, all at the University of North Carolina at Chapel Hill School of Medicine, conducted the research with help from 35 cystic fibrosis patients. All patients had undergone lung transplants because of failing health.

"Several clinical trials, conducted in Europe and the United States, have explored ways to stop or reverse post-transplant osteoporosis but without much success," Aris said. "We think this is the first evidence not only that you can treat osteoporosis after lung transplantation for cystic fibrosis, but also it's the first evidence of a good drug response to osteoporosis after transplant."

Doctors are required to give patients steroids and immuno-suppressants such as cyclosporin to prevent transplanted tissue from being rejected.

"Although these drugs prevent rejection, unfortunately they weaken bones," Aris said. "They impact bones in a half-dozen or more ways such as by blocking calcium absorption in the gut, by promoting bone resorption, or breakdown, and by diminishing new bone formation. Higher fracture rates result after transplantation due in part to these immuno-suppressants."

Twenty-two of 35 lung transplant patients have completed the two-year Pamidronate treatment study at UNC-CH, including one who is an aerobics instructor. Most have markedly increased their activity levels because of improved lung function.

Overall, patients showed a 9 percent increase in their femur (hip) mineral densities and an 11 percent increase in spine mineral densities when compared with control subjects who received no Pamidronate.

Some 200 lung transplants take place in the world each year because of cystic fibrosis, Aris estimated, besides the 10,000 to 20,000 other kinds of organ transplants.

"If you consider all the transplants that take place here and in other countries, that's a very large number of patients who could benefit from this treatment if further studies confirm its effectiveness," he said.

UNC-CH researchers focused on cystic fibrosis lung transplant patients because they had severe osteoporosis, needed quick attention and had similar characteristics that would make the study more reliable, Aris said.

Novartis Pharmaceutical Corp. produces Pamidronate, which is administered intravenously. An oral drug known as Alendronate came on the market less than two years ago for people with osteoporosis from old age. That oral version is now being studied for transplant patients.

Eventually, the treatment may also allow some patients who now are disqualified from transplants because of pre-existing osteoporosis to undergo transplants, the physician said.

The Cystic Fibrosis Foundation funded the UNC-CH research with help from the National Institutes of Health.

By David Williamson, UNC-CH News Services


Story Source:

The above story is based on materials provided by University Of North Carolina At Chapel Hill. Note: Materials may be edited for content and length.


Cite This Page:

University Of North Carolina At Chapel Hill. "UNC-CH Studies Show Medicine Can Reverse Osteoporosis From Transplants, Cystic Fibrosis." ScienceDaily. ScienceDaily, 20 October 1998. <www.sciencedaily.com/releases/1998/10/981020073553.htm>.
University Of North Carolina At Chapel Hill. (1998, October 20). UNC-CH Studies Show Medicine Can Reverse Osteoporosis From Transplants, Cystic Fibrosis. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/1998/10/981020073553.htm
University Of North Carolina At Chapel Hill. "UNC-CH Studies Show Medicine Can Reverse Osteoporosis From Transplants, Cystic Fibrosis." ScienceDaily. www.sciencedaily.com/releases/1998/10/981020073553.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins