Featured Research

from universities, journals, and other organizations

Eat Less To Help Prevent Brain Diseases, Study Suggests

Date:
January 6, 1999
Source:
American Neurological Association
Summary:
Reducing food intake may help protect your brain against age-related disorders such as Alzheimer's disease and Parkinson's disease and improve your recovery from stroke and other acute injuries to the brain, according to a study published in this month's Annals of Neurology, the scientific journal of the American Neurological Association.

Reducing food intake may help protect your brain against age-related disorders such as Alzheimer's disease and Parkinson's disease and improve your recovery from stroke and other acute injuries to the brain, according to a study published in this month's Annals of Neurology, the scientific journal of the American Neurological Association.

In a study of animal models of brain diseases, researchers at the University of Kentucky's Sanders-Brown Center on Aging found they could reduce the effects of experimentally induced injuries to the brain by maintaining rats on reduced diets.

"It's a leap to extrapolate from animal studies to human diseases," said Mark P. Mattson, Ph.D., professor of anatomy and neurobiology at the University of Kentucky, senior author of the report. "However, when you consider these results in light of the evidence that diet reduction reduces risk in humans for cardiovascular diseases and cancer, which involve some of the same cellular mechanisms, it isn't unreasonable to recommend that people reduce food intake as a hedge against neurodegenerative diseases."

Although formal studies of calorie intake and neurodegenerative diseases in humans have not been performed, correlations have been pointed out between the lower caloric intake and lower incidences of Alzheimer's for people in China and Japan compared to the United States and Canada.

In the University of Kentucky study, one group of rats was fed only every other day, consuming 30% fewer calories and weighing 20% less, than a second group whose diet was not restricted. Several months later, the researchers administered toxins that selectively destroy parts of the brain in ways that mimic the destruction wrought by neurodegenerative diseases.

In an experimental model of Alzheimer's disease, the toxin kainic acid was used to damage the hippocampus, a part of the brain involved in learning and memory. In an experimental model of Huntington's disease, the toxin 3-nitropropionic acid was used to damage the striatum, a part of the brain critical for movement.

Scientists are particularly interested in the damage caused to cells by toxins such as kainic acid and 3-nitropropionic acid because it offers clues to the formation of free radicals, molecules that are implicated not only in neurodegenerative diseases and stroke but also in cardiovascular disease and cancer.

The rats whose diets had been restricted were much more resistant to the toxins. Their hippocampal and striatal cells appeared to be buffered from the degeneration that occurred in the corresponding brain areas of the normally fed rats. Similarly, food-restricted rats performed better on learning and memory tests after kainic acid and on movement tests after 3-nitropropionic acid.

Much of the research in age-related neurologic disease is focused on trying to cure or slow down these processes with drugs and other therapeutic approaches. The results of this study, said Mattson, suggest a complementary approach based on educating the public about diet.

Other scientists stress that these data should be viewed cautiously. Until more evidence, especially in humans, becomes available, they feel it is inappropriate to use this study alone to recommend calorie reduction in human diets.

Other authors of the study were Annadora J. Bruce-Keller, PhD, Gloria Umberger, BS, MPH, and Robert McFall, BS, of the University of Kentucky.


Story Source:

The above story is based on materials provided by American Neurological Association. Note: Materials may be edited for content and length.


Cite This Page:

American Neurological Association. "Eat Less To Help Prevent Brain Diseases, Study Suggests." ScienceDaily. ScienceDaily, 6 January 1999. <www.sciencedaily.com/releases/1999/01/990106080443.htm>.
American Neurological Association. (1999, January 6). Eat Less To Help Prevent Brain Diseases, Study Suggests. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/1999/01/990106080443.htm
American Neurological Association. "Eat Less To Help Prevent Brain Diseases, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/1999/01/990106080443.htm (accessed August 28, 2014).

Share This




More Mind & Brain News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins