Featured Research

from universities, journals, and other organizations

New Protein-Like Polymer Shows Promise For Blood Vessel Replacement

Date:
March 25, 1999
Source:
American Chemical Society
Summary:
A new protein-like polymer that supports the growth of endothelial cells and could be used for blood vessel replacement has been designed by researchers at the California Institute of Technology.

ANAHEIM, Calif., March 24 -- A new protein-like polymer that supports the growth of endothelial cells and could be used for blood vessel replacement has been designed by researchers at the California Institute of Technology.

Each year, more than 500,000 people undergo vein or artery replacement therapy, often due to atherosclerosis, a form of hardening of the arteries. The research was presented here today during the week-long national meeting of the American Chemical Society, the world's largest scientific society.

The new material is expected to aid patients who cannot supply their own replacement veins. Typically, replacement of damaged veins or arteries is done by using another blood vessel from elsewhere in the person's body, generally a saphenous vein from the legs or the internal mammary artery that runs along the inside of the breast bone. CalTech's David Tirrell, Ph.D., says, "If a person has atherosclerosis in one artery, he or she may well have it in others. So, often those replacement arteries are not available." Even when they can be used, he points out, success rates are only about 70 percent after five years and even lower with current synthetic polymers used for vascular replacement.

The new polymer, which Tirrell describes as a biomaterial, is "closer to proteins, which gives us more flexibility with respect to the kinds of cellular interactions and mechanical properties we can achieve." Genetic engineering was used to produce analogues of the polymer's key component, elastin, a protein similar to collagen and an essential part of elastic fibers in mammals. Tirrell also credits University of Minnesota researcher Dan Urry with much of the early groundbreaking work on biomedical uses of elastin.

The polymer would be implanted in place of the diseased portion of the artery or vein, says Tirrell, and serve as a matrix within which the body could form its own layer of endothelial cells, which normally line a blood vessel. The cells also could be introduced to the polymer before implantation, he notes. The next step for the new polymer is testing it in laboratory animals, which Tirrell says could be done within the next year or so.

A nonprofit organization with a membership of nearly 159,000 chemists and chemical engineers, the American Chemical Society publishes scientific journals and databases, convenes major research conferences, and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "New Protein-Like Polymer Shows Promise For Blood Vessel Replacement." ScienceDaily. ScienceDaily, 25 March 1999. <www.sciencedaily.com/releases/1999/03/990325053654.htm>.
American Chemical Society. (1999, March 25). New Protein-Like Polymer Shows Promise For Blood Vessel Replacement. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/1999/03/990325053654.htm
American Chemical Society. "New Protein-Like Polymer Shows Promise For Blood Vessel Replacement." ScienceDaily. www.sciencedaily.com/releases/1999/03/990325053654.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins