Featured Research

from universities, journals, and other organizations

Sudden Cardiac Death May Run In Families

Date:
April 20, 1999
Source:
American Heart Association
Summary:
Researchers have shown, for the first time, that sudden cardiac death in men runs in families, according to a study in today's Circulation: Journal of the American Heart Association.

DALLAS, April 20 -- Researchers have shown, for the first time, that sudden cardiac death in men runs in families, according to a study in today's Circulation: Journal of the American Heart Association.

Researchers have long known that a person's genetic blueprint contributes to his or her heart attack risk, but this is the first study to identify a genetic risk for sudden cardiac death, which occurs in about 250,000 individuals each year in the United States.

The study's lead author, Xavier Jouven, M.D., says, "Physicians generally ask patients whether they have a family history of heart attacks. It would now be useful to ask patients about a possible parental history of sudden death." Jouven is a cardiologist at Service de Cardiologie, Hτpital Boucicaut, and epidemiologist at Unite INSERM 258 d'Epidemiologie Cardiovasculaire, Hopital Broussais, Paris.

In this study, The Paris Prospective Study I, sudden death is defined as natural death that occurs within an hour after onset of symptoms. The patient may or may not have had previously diagnosed heart disease.

The risk of sudden death among men whose mother or father had experienced sudden death was almost double that of males whose parents did not suffer sudden death. For men whose mother and father both died of sudden death, the sudden death risk was nine times higher than for those whose parents did not die of sudden death.

Familial history of sudden death may help identify those at high risk for this condition and motivate physicians to advise their patients about how to reduce the risk of heart disease, strokes and sudden death, Jouven says.

Prevention measures would include reducing risk factors such as excessive weight gain, high blood pressure, elevated blood levels of cholesterol, sedentary lifestyle and smoking.

"While we don't know if a parental history of sudden death is also an independent risk factor for women, it would be prudent for women who have a family history of sudden death also to consider preventive health measures," Jouven says.

In the study, researchers followed 7,079 middle-aged men employed by the City of Paris for an average of 23 years. During this period, 2,083 men died -- 118 due to sudden death and 192 due to fatal heart attacks, which were sudden. According to the researchers, a history of sudden death characterized 22 (18.6 percent) of the men who died of sudden death. Of the men who suffered a fatal heart attack -- not a sudden death -- 19 (9.9 percent) had a history of parental sudden death. Of the 6,769 individuals who did not die from either a heart attack or sudden death, only 718 (10.6 percent) had a history of parental sudden death.

Researchers found that a parental history of sudden death was an independent risk factor for predicting sudden death.

Too often, sudden death is the first -- and the last -- sign of heart disease. Of the approximately 250,000 men and women who suffer a sudden cardiac death each year in the United States, only about half were aware of their heart disease. Therefore, being able to identify people at high risk for sudden death is essential to timely intervention with effective preventive measures, says Jouven.

"Until this study, there was no known risk factor for identifying people at increased risk of sudden death other than the known risk factors for coronary heart disease, such as advancing age, obesity, diabetes, tobacco use, and elevations of blood pressure, resting heart rate, and blood cholesterol," Jouven says.

The other co-authors of this study include Michel Desnos, M.D.; Claude Guerot, M.D.; and Pierre Ducimetiθre, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Sudden Cardiac Death May Run In Families." ScienceDaily. ScienceDaily, 20 April 1999. <www.sciencedaily.com/releases/1999/04/990420065119.htm>.
American Heart Association. (1999, April 20). Sudden Cardiac Death May Run In Families. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/1999/04/990420065119.htm
American Heart Association. "Sudden Cardiac Death May Run In Families." ScienceDaily. www.sciencedaily.com/releases/1999/04/990420065119.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins