Featured Research

from universities, journals, and other organizations

Patients Treated Successfully For Hodgkin's Disease Are At 9 Times The Risk For Developing Second Cancers

Date:
May 6, 1999
Source:
University At Buffalo
Summary:
Persons treated for Hodgkin's disease in childhood are at high risk for developing a second malignancy and should be monitored closely by their physicians throughout their lifetime, researchers at the University at Buffalo and Roswell Park Cancer Institute (RPCI) have shown.

UB study shows risk of thyroid cancer 164 times higher for men

Related Articles


SAN FRANCISCO -- Persons treated for Hodgkin's disease in childhood are at high risk for developing a second malignancy and should be monitored closely by their physicians throughout their lifetime, researchers at the University at Buffalo and Roswell Park Cancer Institute (RPCI) have shown.

Results of two studies on this issue were presented here today (May 2, 1999) at the annual meeting of the Society for Pediatric Research.

The findings showed that persons treated for Hodgkin's Disease as children were at nine times the risk of developing a second cancer, with risks of developing certain types of cancer much higher than that, compared to patients without Hodgkin's disease.

The risk of developing thyroid cancer in males was especially high -- 164 times that of controls.

"These are big relative risks," said Daniel M. Green, M.D., UB professor of pediatrics, a specialist in pediatric oncology at RPCI and senior researcher on the studies. "These studies should alert physicians to the need for careful and continuing screening at a much earlier age than the American Cancer Society recommends for the population at large."

The studies involved 182 patients treated at RPCI for Hodgkin's disease between 1960 and 1989. All were less than 20 years old when their disease was diagnosed. By the time they were 30, 27 percent of the patients had developed at least one second cancer, excluding skin cancer. A second study reported on incidence of skin cancer only.

The relative risks for developing one of the more prevalent second cancers were found to be nine times greater than for persons without Hodgkin's disease in both males and females. The relative risk for thyroid cancer was 164 times greater for males and 39 times greater for females; for breast cancer, eight times greater for females; for non-Hodgkin's lymphoma, 15 times greater for males and 23 times greater for females; and leukemia, 19 times greater for males and 25 times greater for females.

"With higher survival rates for Hodgkin's disease, we are going to see more second cancers down the road," said Julie A. Reynolds, M.D., pediatric resident at The Children's Hospital of Buffalo and first author on the study. "We need to look at the data to see the influence of various treatments, and to educate the patient about the need for screening." No one treatment was found to have a significant effect on second-cancer risk.

In the study on basal cell carcinoma alone, headed by Green, findings showed that the most important variable was combined treatment with radiation and chemotherapy.

Of patients who received radiation therapy alone, 3 percent developed skin cancer by the age of 14, and 5.6 percent of patients who received combined therapy developed skin cancer by the time they were 20.

"Children and adolescents who have been treated successfully for Hodgkin's disease should be told about their risk of developing non-melanoma skin cancer, and should receive thorough examinations of the skin and be well-schooled regarding safe sun exposure," Green said.

Additional researchers on the studies were Maurice P. Barcos, M.D., Ph.D., and Michael Zevon, Ph.D., both of UB and RPCI; and R. Jeffrey Lee, MD, and Brenda C. Hall, pediatric nurse practitioner in oncology, both of RPCI.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Patients Treated Successfully For Hodgkin's Disease Are At 9 Times The Risk For Developing Second Cancers." ScienceDaily. ScienceDaily, 6 May 1999. <www.sciencedaily.com/releases/1999/05/990506065945.htm>.
University At Buffalo. (1999, May 6). Patients Treated Successfully For Hodgkin's Disease Are At 9 Times The Risk For Developing Second Cancers. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/1999/05/990506065945.htm
University At Buffalo. "Patients Treated Successfully For Hodgkin's Disease Are At 9 Times The Risk For Developing Second Cancers." ScienceDaily. www.sciencedaily.com/releases/1999/05/990506065945.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins