Featured Research

from universities, journals, and other organizations

Cedars-Sinai Medical Center Study Identifies For The First Time A Molecular Mechanism Behind Hormonal Response To Stress

Date:
June 10, 1999
Source:
Cedars-Sinai Medical Center
Summary:
A two-year study at Cedars-Sinai Medical Center has culminated in the discovery of a molecular mechanism that transduces stress signals from the brain to other regions of the body. These stress signals are produced in response to physical or psychological trauma.

LOS ANGELES (June 8, 1999) -- A two-year study at Cedars-Sinai Medical Center has culminated in the discovery of a molecular mechanism that transduces stress signals from the brain to other regions of the body. These stress signals are produced in response to physical or psychological trauma.

Related Articles


The molecule--leukemia inhibitory factor (LIF)--is the connecting interface between the hypothalamus, the endocrine regulatory center within the brain, and the glands that constitute the endocrine system.

"This is the first documentation of how a novel regulatory cytokine molecule, which is synthesized in the brain, responds and acts appropriately to regulate the release of the pituitary corticotropin (ACTH) hormone, which controls adrenal corticosteroid hormones," explained lead investigator Shlomo Melmed, M.D., director, Cedars-Sinai Research Institute, and senior vice president, Academic Affairs, Cedars-Sinai Medical Center. "LIF acts as an 'on-off' switch, communicating to the endocrine system to produce ACTH, which is secreted by the pituitary to release adrenal steroids. The intrapituitary molecule, suppressor of cytokine signaling (SOCS-3), responds to LIF within the pituitary, allowing very fine tuning of the pituitary response to brain and peripheral signals."

This important discovery, which will be published in the June 7, 1999 issue of Proceedings of the National Academy of Sciences, will provide a tool for researchers studying the endocrine responses that modulate the protection against sepsis (blood-borne infections), shock and inflammation, Dr. Melmed explained. "The stress response to these illnesses protects against the body being overwhelmed by immune or inflammatory insult."

LIF is one of the central triggers from the brain to release hormones in response to acute and chronic illness, trauma, shock, acute and chronic infection and a myriad of other inflammatory conditions, including arthritis and lupus. The endocrine glands function as a control system for the body, with different glands secreting various types of endocrine hormones.

"The adrenal gland's manufacture of corticosteroids (cortisoL) is a classic stress response that is necessary for the body to maintain equilibrium and internal homeostasis," Dr. Melmed said. "We were able to show that the pituitary production of ACTH is regulated by a 'pro-inflammatory cytokine,' LIF, and its pituitary target regulator, SOCS-3."

The research team, which included Cedars-Sinai investigators Corinne Bousquet and Chris Auernhammer, M.D., was able to identify the regulatory structure of SOCS-3, a molecule in the hypothalamus and pituitary, and show how it functions as an "on-off" switch for LIF-induced ACTH secretion. This was accomplished by regulating the LIF activity and allowing the cytokine to signal the pituitary gland to secrete ACTH.

"Pituitary SOCS-3 is thus shown to be the novel molecular connection for transducing the LIF cytokine-mediated brain signals to produce ACTH," Dr. Melmed stated.

An associate dean and professor of medicine at University of California-Los Angeles (UCLA), Dr. Melmed is a principal investigator funded by the National Institutes of Health. He has served as editor in chief for a number of scholarly publications, including Pituitary, Endocrine Updates and Endocrinology, and is widely published in scientific journals. He is also the pituitary editor for major endocrinology and internal medicine textbooks.

Dr. Melmed has received a number of honors and awards: Best Doctors in America (1994-1999); Pituitary Society Award, Contributions to Understanding Pituitary Disease (1997); McGill University, Neuro-Endocrinology Award (1995); and Royal Society of Medicine, Clinical Endocrinology Trust Medal (1994). A graduate of the University of Cape Town School of Medicine, South Africa, he is an elected member of the Association of American Physicians and the American Society of Clinical Investigation.

###

Note to Reporters: To arrange a media interview, please call 310-855-4767.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Cedars-Sinai Medical Center Study Identifies For The First Time A Molecular Mechanism Behind Hormonal Response To Stress." ScienceDaily. ScienceDaily, 10 June 1999. <www.sciencedaily.com/releases/1999/06/990610073809.htm>.
Cedars-Sinai Medical Center. (1999, June 10). Cedars-Sinai Medical Center Study Identifies For The First Time A Molecular Mechanism Behind Hormonal Response To Stress. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/1999/06/990610073809.htm
Cedars-Sinai Medical Center. "Cedars-Sinai Medical Center Study Identifies For The First Time A Molecular Mechanism Behind Hormonal Response To Stress." ScienceDaily. www.sciencedaily.com/releases/1999/06/990610073809.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins