Featured Research

from universities, journals, and other organizations

UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases

Date:
August 5, 1999
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.

DALLAS - August 4, 1999 - Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.

Related Articles


The research, reported in this month's issue of Nature Medicine, involved the molecular engineering of cells in mice - a procedure that could eventually lead to the prevention and treatment of inflammatory diseases such as rheumatoid arthritis.

"What we did was to change the concept entirely. We tried to convert dendritic cells (which signal for an immune response) into cells that deliver death signals instead of activation signals," said Dr. Akira Takashima, the Thomas L. Shields, M.D., Professor in Dermatology.

Dendritic cells are specialized white blood cells that serve an important function within the immune system. Normally they send activation signals to T lymphocytes to begin multiplying and initiate an immune response.

"Sometimes the dendritic cells that can help a person acquire protective immunity are also involved in the induction of harmful immune responses," said Takashima. "There are many diseases, especially inflammatory diseases, where T cells play a pathogenic role."

For example, rheumatoid arthritis is a common inflammatory joint disease believed to be caused by an autoimmune response. Patients' immune systems form antibodies that improperly attack the lining surrounding joints, causing chronic inflammation.

"The next step is to translate our knowledge of dendritic cells and apply this technology into clinical trials for treating the various diseases caused by T cells," Takashima said.

Dr. Hiroyuki Matsue, assistant professor of dermatology at UT Southwestern and primary author of the study, collaborated with Takashima and other researchers from UT Southwestern, including Keiko Matsue, postdoctoral researcher, and Michael Walters, research technician.

National Institutes of Health grants supported the study.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases." ScienceDaily. ScienceDaily, 5 August 1999. <www.sciencedaily.com/releases/1999/08/990805071427.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1999, August 5). UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/1999/08/990805071427.htm
University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases." ScienceDaily. www.sciencedaily.com/releases/1999/08/990805071427.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins