Featured Research

from universities, journals, and other organizations

UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases

Date:
August 5, 1999
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.

DALLAS - August 4, 1999 - Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.

The research, reported in this month's issue of Nature Medicine, involved the molecular engineering of cells in mice - a procedure that could eventually lead to the prevention and treatment of inflammatory diseases such as rheumatoid arthritis.

"What we did was to change the concept entirely. We tried to convert dendritic cells (which signal for an immune response) into cells that deliver death signals instead of activation signals," said Dr. Akira Takashima, the Thomas L. Shields, M.D., Professor in Dermatology.

Dendritic cells are specialized white blood cells that serve an important function within the immune system. Normally they send activation signals to T lymphocytes to begin multiplying and initiate an immune response.

"Sometimes the dendritic cells that can help a person acquire protective immunity are also involved in the induction of harmful immune responses," said Takashima. "There are many diseases, especially inflammatory diseases, where T cells play a pathogenic role."

For example, rheumatoid arthritis is a common inflammatory joint disease believed to be caused by an autoimmune response. Patients' immune systems form antibodies that improperly attack the lining surrounding joints, causing chronic inflammation.

"The next step is to translate our knowledge of dendritic cells and apply this technology into clinical trials for treating the various diseases caused by T cells," Takashima said.

Dr. Hiroyuki Matsue, assistant professor of dermatology at UT Southwestern and primary author of the study, collaborated with Takashima and other researchers from UT Southwestern, including Keiko Matsue, postdoctoral researcher, and Michael Walters, research technician.

National Institutes of Health grants supported the study.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases." ScienceDaily. ScienceDaily, 5 August 1999. <www.sciencedaily.com/releases/1999/08/990805071427.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1999, August 5). UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/1999/08/990805071427.htm
University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Engineer Cells That May Hold Key To Treating Inflammatory Diseases." ScienceDaily. www.sciencedaily.com/releases/1999/08/990805071427.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins