Featured Research

from universities, journals, and other organizations

Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides

Date:
September 9, 1999
Source:
University At Buffalo
Summary:
University at Buffalo researchers have shown for the first time that a variant of the apolipoprotein E (apoE) gene, known as apoE 4, may increase the risk of breast cancer by inhibiting the elimination of serum triglycerides from the bloodstream.

ATHENS -- University at Buffalo researchers have shown for the first time that a variant of the apolipoprotein E (apoE) gene, known as apoE 4, may increase the risk of breast cancer by inhibiting the elimination of serum triglycerides from the bloodstream.

Related Articles


While women with the highest triglyceride levels had a slight increase in risk of breast cancer, those with the highest levels, plus the apoE 4 genotype, had a four-fold increase in risk.

"We think that apoE 4 keeps serum triglyceride levels elevated by reducing their clearance," said Kirsten Moysich, Ph.D., a molecular epidemiologist at UB and Roswell Park Cancer Institute, who is working with colleagues from the UB Department of Social and Preventive Medicine. "Triglycerides themselves appear to be a risk factor for breast cancer by reducing sex-hormone-binding globulin levels, which may lead to higher endogenous estrogen levels. This genotype seems to keep levels of triglycerides constantly high."

Moysich presented her findings here today (Sept. 6) at the annual meeting of the International Society for Environmental Epidemiology. The study also has been accepted for publication.

The apoE gene in its three variations -- e2, e3 and e4 -- is involved in lipid metabolism. The e4 variant has been associated with elevated levels of cholesterol and triglycerides, and with an increased risk of coronary disease and Alzheimer's disease, Moysich said.

To determine if apoE 4 also influences the association between serum triglycerides and breast cancer, Moysich and colleagues analyzed blood samples from 256 women with primary breast cancer and 325 controls for triglyceride levels and apoE genotype. Twenty-four percent of the women in the study were found to have the apoE 4 gene.

The results showed no relationship between increased breast-cancer risk and apoE genotype when comparing only genotypes. Women with the highest levels of triglycerides were found to be at a 70-percent-greater risk than women with the lowest levels. But when comparing triglyceride levels and breast-cancer risk among apoE genotypes, triglycerides were associated with elevated risk only in women with the e4 genotype.

Moysich said that if these results can be replicated, researchers will gain further understanding of the role of dietary factors and serum lipids in breast-cancer development.

Also contributing to the study were Julie Baker, a doctoral student, and Jo L. Freudenheim, Ph.D., professor, both in the UB Department of Social and Preventive Medicine; Christine Ambrosone, Ph.D., formerly with UB and now a molecular epidemiologist with the Food and Drug Administration, and Elise Bowman, research associate, and Peter G. Shields, M.D., of the National Cancer Institute.

The study was funded by grants from the National Cancer Institute and the National Institute for Environmental Health and Safety.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides." ScienceDaily. ScienceDaily, 9 September 1999. <www.sciencedaily.com/releases/1999/09/990909080356.htm>.
University At Buffalo. (1999, September 9). Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/1999/09/990909080356.htm
University At Buffalo. "Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides." ScienceDaily. www.sciencedaily.com/releases/1999/09/990909080356.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins