Featured Research

from universities, journals, and other organizations

Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides

Date:
September 9, 1999
Source:
University At Buffalo
Summary:
University at Buffalo researchers have shown for the first time that a variant of the apolipoprotein E (apoE) gene, known as apoE 4, may increase the risk of breast cancer by inhibiting the elimination of serum triglycerides from the bloodstream.

ATHENS -- University at Buffalo researchers have shown for the first time that a variant of the apolipoprotein E (apoE) gene, known as apoE 4, may increase the risk of breast cancer by inhibiting the elimination of serum triglycerides from the bloodstream.

Related Articles


While women with the highest triglyceride levels had a slight increase in risk of breast cancer, those with the highest levels, plus the apoE 4 genotype, had a four-fold increase in risk.

"We think that apoE 4 keeps serum triglyceride levels elevated by reducing their clearance," said Kirsten Moysich, Ph.D., a molecular epidemiologist at UB and Roswell Park Cancer Institute, who is working with colleagues from the UB Department of Social and Preventive Medicine. "Triglycerides themselves appear to be a risk factor for breast cancer by reducing sex-hormone-binding globulin levels, which may lead to higher endogenous estrogen levels. This genotype seems to keep levels of triglycerides constantly high."

Moysich presented her findings here today (Sept. 6) at the annual meeting of the International Society for Environmental Epidemiology. The study also has been accepted for publication.

The apoE gene in its three variations -- e2, e3 and e4 -- is involved in lipid metabolism. The e4 variant has been associated with elevated levels of cholesterol and triglycerides, and with an increased risk of coronary disease and Alzheimer's disease, Moysich said.

To determine if apoE 4 also influences the association between serum triglycerides and breast cancer, Moysich and colleagues analyzed blood samples from 256 women with primary breast cancer and 325 controls for triglyceride levels and apoE genotype. Twenty-four percent of the women in the study were found to have the apoE 4 gene.

The results showed no relationship between increased breast-cancer risk and apoE genotype when comparing only genotypes. Women with the highest levels of triglycerides were found to be at a 70-percent-greater risk than women with the lowest levels. But when comparing triglyceride levels and breast-cancer risk among apoE genotypes, triglycerides were associated with elevated risk only in women with the e4 genotype.

Moysich said that if these results can be replicated, researchers will gain further understanding of the role of dietary factors and serum lipids in breast-cancer development.

Also contributing to the study were Julie Baker, a doctoral student, and Jo L. Freudenheim, Ph.D., professor, both in the UB Department of Social and Preventive Medicine; Christine Ambrosone, Ph.D., formerly with UB and now a molecular epidemiologist with the Food and Drug Administration, and Elise Bowman, research associate, and Peter G. Shields, M.D., of the National Cancer Institute.

The study was funded by grants from the National Cancer Institute and the National Institute for Environmental Health and Safety.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides." ScienceDaily. ScienceDaily, 9 September 1999. <www.sciencedaily.com/releases/1999/09/990909080356.htm>.
University At Buffalo. (1999, September 9). Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/1999/09/990909080356.htm
University At Buffalo. "Buffalo Scientists Find Breast-Cancer Risk May Be Influenced By Gene That Regulates Serum Triglycerides." ScienceDaily. www.sciencedaily.com/releases/1999/09/990909080356.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins