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Mutation In PTEN Gene Can Cause Cancer And Autoimmune Disease

Date:
September 27, 1999
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
Although it has been known that a mutation in both copies of the PTEN tumor suppressor gene impairs a cell's ability to program its death, researchers have found that losing function of only one of the pair is enough to disrupt this vital signaling mechanism. Their findings, published in the September 24 issue of the journal Science, show that inactivation of just one PTEN gene allows some white blood cells to accumulate unchecked and "attack" their own organs.

New York, September 23 - Although it has been known that a mutation in both copies of the PTEN tumor suppressor gene impairs a cell's ability to program its death, researchers have found that losing function of only one of the pair is enough to disrupt this vital signaling mechanism. Their findings, published in the September 24 issue of the journal Science, show that inactivation of just one PTEN gene allows some white blood cells to accumulate unchecked and "attack" their own organs. This process, studied in mice, eventually results in the development of chronic fatal conditions that may include cancer and an autoimmune disease.


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The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


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Memorial Sloan-Kettering Cancer Center. "Mutation In PTEN Gene Can Cause Cancer And Autoimmune Disease." ScienceDaily. ScienceDaily, 27 September 1999. <www.sciencedaily.com/releases/1999/09/990927065349.htm>.
Memorial Sloan-Kettering Cancer Center. (1999, September 27). Mutation In PTEN Gene Can Cause Cancer And Autoimmune Disease. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/1999/09/990927065349.htm
Memorial Sloan-Kettering Cancer Center. "Mutation In PTEN Gene Can Cause Cancer And Autoimmune Disease." ScienceDaily. www.sciencedaily.com/releases/1999/09/990927065349.htm (accessed April 18, 2014).

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