Featured Research

from universities, journals, and other organizations

Material That Made Car Bumpers Shine Finds A Role In Manufacture Of Drugs, Dyes

Date:
October 27, 1999
Source:
University Of Rochester
Summary:
Chemists have a gleam in their eyes-from the reflection of chrome bumpers that adorn classic roadsters. The raw material at the root of the bumpers' sheen, chromium, is helping University of Rochester chemists leapfrog into the future by providing an automated way to create hundreds of thousands of compounds in a few easy steps.

Chemists have a gleam in their eyes-from the reflection of chrome bumpers that adorn classic roadsters. The raw material at the root of the bumpers' sheen, chromium, is helping University of Rochester chemists leapfrog into the future by providing an automated way to create hundreds of thousands of compounds in a few easy steps. The classic compound, long used in a variety of chemical reactions, now is part of a new process to create materials known as anilines that are used in the manufacture of drugs, dyes, plastics and film.

The findings published recently in the chemistry journal Angewandte Chemie are part of a research program in combinatorial chemistry, a field where chemists create and screen thousands or even millions of compounds simultaneously for a given application. A paper by post-doctoral researcher Anitha Hari and Benjamin Miller, assistant professor of chemistry, shows how chromium chloride makes it possible to use combinatorial chemistry in the manufacture of anilines. Such a development could speed up the screening of the compounds for a wide variety of industrial products, says Miller.

The Rochester chemists have shown how chromium chloride can be used to energize a rare solid-to-solid catalytic reaction that makes it possible to produce a huge variety of anilines simultaneously. Chromium chloride shuttles back and forth between two solid substrates, converting raw materials to anilines.

"You can't just bang two solids up against each other and have them react," says Miller, whose research project was supported by Eastman Kodak Co. "You need a catalyst that can migrate from one material to the other."

Traditionally scientists produce anilines by starting with powdery compounds known as nitroarenes, which are dissolved in a solvent like a packet of Kool-Aid powder dissolves in water. Then chemists use palladium as a catalyst to convert the nitroarenes to anilines, which chemists separate out and purify in a time-consuming process.

In Miller's configuration, the raw nitroarenes are fixed on polymer beads that are then immersed in a solvent; the material clings to the beads like algae to a set of buoys. Also in the solvent is a strip of manganese. Chromium chloride acts as a catalyst, going back and forth between the strand of polymer beads and the strip of manganese and converting nitroarenes to anilines. Schematically the process is a reminder of the old video game Pong, where a ball bounces back and forth between two paddles; in this case the "ball" is a chromium chloride molecule that goes back and forth between the polymer beads and the manganese strip. The nitroarenes are converted to anilines right on the polymer beads, and the chromium is continually regenerated by the manganese.

By slightly altering the properties of the polymer beads, each about the size of a grain of sand, Miller can produce a huge variety of anilines, even hundreds of thousands of different types in just one experiment. The system acts as a tiny factory producing different chemical compounds that a drug company might then test in a hunt for a new drug. The anilines are very easy to separate out-chemists simply pull out the polymer beads and wash off the anilines. Because the chromium, which is very expensive and toxic in high amounts, is recycled by the manganese, there's little residue left on the anilines.


Story Source:

The above story is based on materials provided by University Of Rochester. Note: Materials may be edited for content and length.


Cite This Page:

University Of Rochester. "Material That Made Car Bumpers Shine Finds A Role In Manufacture Of Drugs, Dyes." ScienceDaily. ScienceDaily, 27 October 1999. <www.sciencedaily.com/releases/1999/10/991027072135.htm>.
University Of Rochester. (1999, October 27). Material That Made Car Bumpers Shine Finds A Role In Manufacture Of Drugs, Dyes. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/1999/10/991027072135.htm
University Of Rochester. "Material That Made Car Bumpers Shine Finds A Role In Manufacture Of Drugs, Dyes." ScienceDaily. www.sciencedaily.com/releases/1999/10/991027072135.htm (accessed August 28, 2014).

Share This




More Matter & Energy News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Australian Airlines Relax Phone Ban Too

Australian Airlines Relax Phone Ban Too

Reuters - Business Video Online (Aug. 26, 2014) Qantas and Virgin say passengers can use their smartphones and tablets throughout flights after a regulator relaxed a ban on electronic devices during take-off and landing. As Hayley Platt reports the move comes as the two domestic rivals are expected to post annual net losses later this week. Video provided by Reuters
Powered by NewsLook.com
Hurricane Marie Brings Big Waves to California Coast

Hurricane Marie Brings Big Waves to California Coast

Reuters - US Online Video (Aug. 26, 2014) Huge waves generated by Hurricane Marie hit the Southern California coast. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Chinese Researchers Might Be Creating Supersonic Submarine

Chinese Researchers Might Be Creating Supersonic Submarine

Newsy (Aug. 26, 2014) Chinese researchers have expanded on Cold War-era tech and are closer to building a submarine that could reach the speed of sound. Video provided by Newsy
Powered by NewsLook.com
Breakingviews: India Coal Strained by Supreme Court Ruling

Breakingviews: India Coal Strained by Supreme Court Ruling

Reuters - Business Video Online (Aug. 26, 2014) An acute coal shortage is likely to be aggravated as India's supreme court declared government coal allocations illegal, says Breakingviews' Peter Thal Larsen. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins