Featured Research

from universities, journals, and other organizations

Estrogen-Driven Gene Activates Human Pituitary Tumors, Cedars-Sinai Medical Center Researchers Find

Date:
November 2, 1999
Source:
Cedars-Sinai Medical Center
Summary:
Estrogen stimulates a newly discovered oncogene in the pituitary gland, setting the stage for cell proliferation, a team of Cedars-Sinai Medical Center researchers report in today's issue of the eminent scientific journal Nature Medicine.

Estrogen stimulates a newly discovered oncogene in the pituitary gland, setting the stage for cell proliferation, a team of Cedars-Sinai Medical Center researchers report in today's issue of the eminent scientific journal Nature Medicine.

Related Articles


"It has been known for many years that estrogen causes the pituitary to become hypervascular -- during pregnancy, it doubles in size -- but there has never been a proven link between estrogen and the mechanism of pituitary tumor development," said senior author Shlomo Melmed, M.D., director of Cedars-Sinai's Burns and Allen Research Institute and the Medical Center's senior vice president, Academic Affairs.

Pituitary tumors account for the most common intracranial neoplasms. Rarely malignant, they nonetheless cause a variety of disorders by generating excess hormones pivotal to growth and reproduction, thyroid and adrenal function.

This finding builds on the landmark 1997 discovery in Dr. Melmed's laboratory of the oncogene PTTG1 (pituitary tumor-transforming gene). Dr. Lin Pei, now a research endocrinologist at Cedars-Sinai, was primary author on a paper that described how overexpression of the gene leads to unbalanced division of chromosomes and subsequent tumor development (Mol. Endocrinol. 11,433-441; 1997).

Once the gene was sequenced in rat genomes, the Cedars-Sinai team sequenced and described its expression in human cells. A novel family of related PTTG oncogenes has since been identified at the institution.

Anthony P. Heaney, M.D., is the primary author of today's report, which has important implications for understanding human development, reproduction, adrenal and thyroid function, and pituitary cancer.

Pituitary tumors are more common in women than in men, reflecting estrogen's importance in tumor development. In men, pituitary tumors express excess estrogen receptors.

Awaiting publication is an important related discovery that PTTG is expressed in other forms of cancer, and that estrogen is linked to its insidious trigger of malignant cell growth in those organs as well.

Now researchers can begin to correlate expression of the gene with stages and lethality of various cancers, not just pituitary tumors, Dr. Melmed said.

A deeper understanding of various forms of PTTG and their actions will lead to improved cancer diagnosis, assessment of cancer progression, and treatment, particularly if ways can be found to disable these estrogen-driven accelerators of cell growth and transformation.

The paper's other authors, along with Heaney and Melmed, are Gregory A. Horwitz, Zhiyong Wang, Ph.D., and Regina Singson. The work was supported by a grant from the National Institutes of Health and a Fulbright Research Scholarship to Dr. Heaney. It was performed in the Doris Factor Molecular Endocrinology Laboratory at Cedars-Sinai.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Estrogen-Driven Gene Activates Human Pituitary Tumors, Cedars-Sinai Medical Center Researchers Find." ScienceDaily. ScienceDaily, 2 November 1999. <www.sciencedaily.com/releases/1999/11/991101152739.htm>.
Cedars-Sinai Medical Center. (1999, November 2). Estrogen-Driven Gene Activates Human Pituitary Tumors, Cedars-Sinai Medical Center Researchers Find. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/1999/11/991101152739.htm
Cedars-Sinai Medical Center. "Estrogen-Driven Gene Activates Human Pituitary Tumors, Cedars-Sinai Medical Center Researchers Find." ScienceDaily. www.sciencedaily.com/releases/1999/11/991101152739.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins