Featured Research

from universities, journals, and other organizations

Researchers Discover Diagnostic Marker For Schizophrenia

Date:
November 23, 1999
Source:
Johns Hopkins Medical Institutions
Summary:
Johns Hopkins researchers have identified a chemical marker in cerebral spinal fluid (CSF) that may help doctors treat and diagnose individuals with schizophrenia.

Johns Hopkins researchers have identified a chemical marker in cerebral spinal fluid (CSF) that may help doctors treat and diagnose individuals with schizophrenia. "Finding this activity in CSF could give us the first real tool for identifying patients with schizophrenia," says Frances Yee, Ph.D., a postdoctoral fellow at the Stanley Neurovirology Laboratory.

Related Articles


For several years, researchers have found evidence that retroviruses may be associated with some cases of schizophrenia. Because retroviruses can't reproduce by themselves, they exploit living host cells and use an enzyme called reverse transcriptase (RT) to copy themselves into host genomes and replicate. In 1998, Yee and colleagues discovered that individuals with schizophrenia had higher levels of RT enzyme activity in their post mortem brain tissue.

As a next step, researchers tested activity levels of this enzyme in the CSF of 18 schizophrenic patients and 18 similar individuals unaffected by the disease. The researchers found that patients with a recent onset of schizophrenia had significantly higher levels, almost a fourfold increase, of RT activity in their CSF in comparison to the controls.

Yee and her team plan to launch a study in a larger group of patients and have hopes that, in the future, this marker could be used to diagnose and treat schizophrenia. "If you have a marker where you can say, if this goes up they are going to have a psychotic episode,' then you might use a slightly different mix of drugs to treat them," says Yee.

Results of Yee's study were reported at the Fifth Annual Symposium on the Neurovirology and Neuroimmunology of Schizophrenia and Bipolar Disorder. The symposium was held Nov. 4 in Bethesda, Maryland.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Researchers Discover Diagnostic Marker For Schizophrenia." ScienceDaily. ScienceDaily, 23 November 1999. <www.sciencedaily.com/releases/1999/11/991123080202.htm>.
Johns Hopkins Medical Institutions. (1999, November 23). Researchers Discover Diagnostic Marker For Schizophrenia. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/1999/11/991123080202.htm
Johns Hopkins Medical Institutions. "Researchers Discover Diagnostic Marker For Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/1999/11/991123080202.htm (accessed October 24, 2014).

Share This



More Mind & Brain News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins