Featured Research

from universities, journals, and other organizations

University Of Iowa Study Looks At Cellular Mechanism Involved In Hypertension

Date:
January 5, 2000
Source:
University Of Iowa
Summary:
A University of Iowa researcher has reported a key finding on a basic cellular mechanism involved in hypertension and how this plays a role in Liddle's syndrome, a rare, genetic form of the disease.

IOWA CITY, Iowa -- A University of Iowa researcher has reported a key finding on a basic cellular mechanism involved in hypertension and how this plays a role in Liddle's syndrome, a rare, genetic form of the disease.

Related Articles


The research, published in the Jan. 1 issue of the Journal of Clinical Investigation, by Peter M. Snyder, M.D., UI assistant professor of internal medicine, centers on ion channels in cells called epithelial sodium channels (ENaC). These channels form the pathway for sodium to move across cells in the kidney, making them a critical regulator of blood pressure. Too much sodium absorption through these channels can lead to an increase in blood pressure, causing hypertension.

"It's been known that genetic mutations in ENaC cause a rare form of hypertension called Liddle's syndrome, but we thought ENaC could also be involved in more common forms of hypertension," Snyder said. "So, the basis of this study was to look at how these channels are regulated."

Previous research has shown that ENaC are regulated by a hormone called vasopressin, which is released by the brain in response to dehydration. Vasopressin signals the cell to increase production of a chemical "messenger" inside the cell called cyclic AMP (cAMP), leading to an increase in sodium absorption through ENaC. Snyder's goal was to better understand how this hormone actually performs its function, he said.

In his study using rat cells, Snyder found that vasopressin regulates ENaC by causing the channels to move to the cell surface, a process called translocation.

"Normally, most of the sodium channels are inside the cell in an intracellular pool. However, when these channels are stimulated by vasopressin and cAMP, this causes them to move to the cell surface. As a result, this increases the amount of sodium absorption in the kidneys and thus increases blood pressure."

In Liddle's syndrome, Snyder found that this cAMP regulation is defective, resulting in excessive sodium absorption in the kidney.

The next step, Snyder said, is to understand exactly how vasopressin and cAMP stimulate the movement of ENaC to the cell surface. This could help researchers identify proteins or other cell structures involved in this process and determine if abnormalities in these proteins could play a role in hypertension.

Future studies will also investigate whether the regulation of ENaC by cAMP is defective in patients with more common forms of hypertension.

Snyder's research was funded by the National Heart, Lung and Blood Institute and the National Institute of Diabetes and Digestive and Kidney Diseases, both part of the National Institutes of Health, and the Roy J. Carver Charitable Trust.


Story Source:

The above story is based on materials provided by University Of Iowa. Note: Materials may be edited for content and length.


Cite This Page:

University Of Iowa. "University Of Iowa Study Looks At Cellular Mechanism Involved In Hypertension." ScienceDaily. ScienceDaily, 5 January 2000. <www.sciencedaily.com/releases/2000/01/000105044403.htm>.
University Of Iowa. (2000, January 5). University Of Iowa Study Looks At Cellular Mechanism Involved In Hypertension. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2000/01/000105044403.htm
University Of Iowa. "University Of Iowa Study Looks At Cellular Mechanism Involved In Hypertension." ScienceDaily. www.sciencedaily.com/releases/2000/01/000105044403.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Teen E-Cigarette Use Triples, Government Debates Regulations

Teen E-Cigarette Use Triples, Government Debates Regulations

Newsy (Apr. 19, 2015) The Centers for Disease Control and Prevention says in 2014, 13.4 percent of high school students reported smoking an e-cigarette within 30 days. Video provided by Newsy
Powered by NewsLook.com
India's Bidi Workers Suffer for 1,000-a-Day Habit

India's Bidi Workers Suffer for 1,000-a-Day Habit

AFP (Apr. 19, 2015) Popular because of their cheap price, bidis are the main source of income for millions of women and children who manufacture these Indian traditional cigarettes for roughly a dollar a day in dire conditions. Duration: 02:26 Video provided by AFP
Powered by NewsLook.com
Elmo Teams Up With Surgeon General To Promote Vaccinations

Elmo Teams Up With Surgeon General To Promote Vaccinations

Newsy (Apr. 18, 2015) Surgeon General Vivek Murthy released a video with Elmo to promote vaccinations. The video was released the same day the measles outbreak ended. Video provided by Newsy
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins