Featured Research

from universities, journals, and other organizations

Discovery Of Protein Controlling Fat Cell Development May Lead To Treatments For Obesity, Related Diseases, National Jewish And Veteran’s Affairs Researchers Find

Date:
January 13, 2000
Source:
National Jewish Medical And Research Center
Summary:
New ways of regulating a protein that binds to DNA in fat cells could lead to treatments for obesity, diabetes and heart disease in the future.

DENVER -- New ways of regulating a protein that binds to DNA in fat cells could lead to treatments for obesity, diabetes and heart disease in the future. Researchers have long known that obesity can result from fat cells increasing in volume--recent studies suggest that fat cells also increase in number--although until this discovery it was unknown what regulated the development of new fat cells. Understanding these controls may be key to the treatment of obesity.

“This protein, CREB, is vital in the creation and maintenance of fat cell development,” said Dwight J. Klemm, Ph.D., associate professor at National Jewish Medical and Research Center and lead author of the article announcing the finding in the February issue of the prestigious scientific journal, Molecular and Cellular Biology.

Researchers at National Jewish and the Denver Veteran’s Affairs Medical Center have discovered a new way to control fat cell development, which could have important implications for the treatment and management of obesity and related diseases, like heart disease and diabetes. The discovery is the culmination of more than 3 years of research into the behavior of fat cells, and the agents that control their growth and development.

“Although much of society believes that all fat is bad, most fat cells are an important component in the regulation of the body’s metabolism,” said Jane E.B. Reusch, M.D., assistant professor of Medicine at the University of Colorado Health Sciences Center and Denver Veteran’s Affairs Medical Center and co-author of the article. “For example, mature fat cells tell your brain you don’t need to eat. This message gets misinterpreted in obesity.”

Immature fat cells play a role in causing obesity by sending signals to the brain that a person is hungry. In people who are obese, fat cells become stuck in an immature state that doesn’t seem to decrease appetite as effectively, causing the body to create additional fat cells. Using a negative version of cyclic adenosine monophosphate response element binding protein (CREB), researchers were able to regulate fat cell development by inserting the protein into fat cell DNA. When negative CREB is inserted into fat cells it prevents normal CREB from binding to DNA in the fat cell. By doing this, the development of new fat cells can be inhibited.

“Fat cell development is an intensive area of research in obesity,” Dr. Klemm said. “This research also has potentially substantial benefits for people with diabetes and heart disease.”

Obesity is the result of numerous and interacting behavioral, physiological and biochemical factors, and is a major health concern in the United States and other nations. More than 33 percent of all Americans are overweight, and excess body fat contributes to the development and seriousness of other diseases, such as heart disease and diabetes.

“We are very excited about this discovery because understanding that this protein controls fat cell development could help us develop new strategies to treat obesity and related diseases,” Dr. Reusch said.

Researchers now will begin using CREB to treat obesity in laboratory animals in an effort to discover ways the protein can be safely and effectively used in medical treatments for humans.

The Number 1 Respiratory Hospital in the U.S. for Two Consecutive Years, U.S. News & World Report, 1998-2000.

Web site: http://www.nationaljewish.org/pa


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "Discovery Of Protein Controlling Fat Cell Development May Lead To Treatments For Obesity, Related Diseases, National Jewish And Veteran’s Affairs Researchers Find." ScienceDaily. ScienceDaily, 13 January 2000. <www.sciencedaily.com/releases/2000/01/000112151359.htm>.
National Jewish Medical And Research Center. (2000, January 13). Discovery Of Protein Controlling Fat Cell Development May Lead To Treatments For Obesity, Related Diseases, National Jewish And Veteran’s Affairs Researchers Find. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2000/01/000112151359.htm
National Jewish Medical And Research Center. "Discovery Of Protein Controlling Fat Cell Development May Lead To Treatments For Obesity, Related Diseases, National Jewish And Veteran’s Affairs Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2000/01/000112151359.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins