February 2, 2000
University Of Pennsylvania Medical Center
Researchers at the University of Pennsylvania Medical Center report development of a strain of mice in whom pregnancy leads to a condition that closely models intrauterine growth retardation, opening the way for scientists to better understand IUGR and develop interventions to effectively treat it.
Despite advances in prenatal care, about one in twenty babies in the United States are severely underweight at birth -- below the 10th percentile -- resulting in significantly higher rates of infant mortality and childhood disease in that group. Reductions in mental capacities and a vulnerability to heart disease and other difficulties in adult life have been linked to the low-birth weight condition, known as intrauterine growth retardation, or IUGR. While some risk factors have been identified -- most prominently, cigarette smoking, diabetes, and nutritional deprivation of the placenta due to high blood pressure -- the direct cause or causes of IUGR are not known. Prevention and treatment have lagged accordingly.
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University Of Pennsylvania Medical Center. "Common Anti-Inflammatory Drug Rescues Low-Growth Fetuses In Mouse Study." ScienceDaily. ScienceDaily, 2 February 2000. <www.sciencedaily.com/releases/2000/02/000202080346.htm>.
University Of Pennsylvania Medical Center. (2000, February 2). Common Anti-Inflammatory Drug Rescues Low-Growth Fetuses In Mouse Study. ScienceDaily. Retrieved March 10, 2014 from www.sciencedaily.com/releases/2000/02/000202080346.htm
University Of Pennsylvania Medical Center. "Common Anti-Inflammatory Drug Rescues Low-Growth Fetuses In Mouse Study." ScienceDaily. www.sciencedaily.com/releases/2000/02/000202080346.htm (accessed March 10, 2014).