Featured Research

from universities, journals, and other organizations

Nose Drop Drug Helps Fight AIDS-Related Cancer

Date:
February 15, 2000
Source:
University Of Southern California
Summary:
An anti-angiogenesis drug, delivered as a nose drop, can bring on the death of tumor cells and even result in remission in patients with AIDS- related Kaposi¹s Sarcoma (KS), according to a study published in the February issue of the Journal of Clinical Oncology by researchers from the USC/Norris Comprehensive Cancer Center.

An anti-angiogenesis drug, delivered as a nose drop, can bring on the death of tumor cells and even result in remission in patients with AIDS- related Kaposi¹s Sarcoma (KS), according to a study published in the February issue of the Journal of Clinical Oncology by researchers from the USC/Norris Comprehensive Cancer Center.

Related Articles


This is the first treatment aimed at disrupting the production of new blood vessels to be successful against the most common malignancy associated with the human immunodeficiency virus, for which there is currently no cure.

A total of 44 patients -- 42 men and 2 women -- with KS were enrolled in an open-label Phase I/II trial of IM862, a tiny protein normally made in the thymus gland. Five of the patients taking the drug experienced a complete remission, and 11 showed a partial remission, for a major response rate of 36 percent.

"And all this occurred with very few side effects, which were limited mostly to mild headaches," said the study¹s principal investigator, Parkash Gill, M.D., professor of medicine and pathology at the Keck School of Medicine of the University of Southern California.

IM862 not only works, but it works quickly: The median amount of time it took for patients in the Phase I/II trials to respond was six to eight weeks. "It can take as much as 20-some weeks to see a complete response," said Gill, "but that¹s still fairly rapid."

And the drug¹s response lasts, as well. For 21 of the patients, the stabilization or regression of their disease has lasted between 7 and 72 weeks or more (at the time the data was compiled) -- even after they stopped taking the drug. "We have a number of patients who after stopping therapy have still not relapsed," Gill said.

The trial was conducted at the USC/Norris Comprehensive Cancer Center and Massachusetts General Hospital. Gill first unveiled his findings at the 35th annual meeting of the American Society of Clinical Oncology last May.

IM862, a peptide, is in development at Cytran Inc., of Kirkland, Wash. Its anti-angiogenic effect appears to be the result of a reduction in the production of a hormone called vascular endothelial growth factor (VEGF), said Gill. VEGF is the hormone responsible for new blood-vessel growth in the body. IM862 also appears to have immune system effects, enhancing the production of chemicals like interleukin-12 and thereby stimulating the body¹s so-called natural killer (NK) cells.

These two actions are closely intertwined. "NK cells produce factors that are toxic to endothelial cells," Gill explained, which means they can slow the growth of blood vessels as well as attack the tumor itself.

Recent laboratory analyses have shown that animals with pancreatic tumors who are treated with IM862 not only have a reduced rate of tumor growth, but have lower levels of VEGF as well. "This confirms quite nicely that at least one of the ways the drug is working is by anti-angiogenesis," Gill said.

Phase III trials of IM862 are now underway at the USC/Norris. In addition, IM862 is currently being tested as a treatment for ovarian cancer, colorectal cancer and melanoma. Gill and his colleagues are planning to begin a trial for prostate cancer, as well.

###

EDITORS: See Anil Tulpule, David T. Scadden, Byron M. Espina, Suzanne Cabriales, Walter Howard, Kathleen Shea, Parkash Gill, "Results of a Randomized Study of IM862 Nasal Solution in the Treatment of AIDS-related Kaposi¹s Sarcoma," Journal of Clinical Oncology, Vol. 18, No. 4, [February] 2000.


Story Source:

The above story is based on materials provided by University Of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University Of Southern California. "Nose Drop Drug Helps Fight AIDS-Related Cancer." ScienceDaily. ScienceDaily, 15 February 2000. <www.sciencedaily.com/releases/2000/02/000215064508.htm>.
University Of Southern California. (2000, February 15). Nose Drop Drug Helps Fight AIDS-Related Cancer. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2000/02/000215064508.htm
University Of Southern California. "Nose Drop Drug Helps Fight AIDS-Related Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/02/000215064508.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins