Featured Research

from universities, journals, and other organizations

Progress In Mental Retardation Research

Date:
February 17, 2000
Source:
Cold Spring Harbor Laboratory
Summary:
A major rationale for genome sequencing is the promise of understanding human disorders, as articles in Genome Research often remind us. This month, in a report on recent progress in mental retardation (MR) research, Jozef Gécz and John Mulley (University of Adelaide) explain how advances in human genome sequencing have helped uncover genes involved in MR.

A major rationale for genome sequencing is the promise of understanding human disorders, as articles in Genome Research often remind us. This month, in a report on recent progress in mental retardation (MR) research, Jozef Gécz and John Mulley (University of Adelaide) explain how advances in human genome sequencing have helped uncover genes involved in MR.

Related Articles


Mental retardation, defined as IQ under 70, affects two to three percent of the population, either as part of a complex syndrome (e.g., Down syndrome) or by itself (non-specific MR). Many different gene defects can cause non-specific MR, including a variety of mutations on the X chromosome that mostly affect males. Because sufferers with different mutations can have similar symptoms, pinpointing individual genes for MR is difficult. In this review, Gécz and Mulley describe how sequence data and resources derived from the Human Genome Project have come together with traditional genetic studies to jumpstart research on non-specific mental retardation.

As a result, scientists have recently identified seven X-linked genes whose mutations cause non-specific MR, among an estimated 20-100 such genes on the X chromosome and possibly hundreds altogether on the human genome. Interestingly, most of the identified genes participate in intracellular signaling and are highly active in the hippocampus, a brain region involved in human memory. With the advent of new genomic technologies such as DNA arrays, say Gécz and Mulley, we might realistically hope to identify all genes involved in mental retardation. Such an achievement would illuminate not only the causes of mental retardation but also the workings of the healthy human brain.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Progress In Mental Retardation Research." ScienceDaily. ScienceDaily, 17 February 2000. <www.sciencedaily.com/releases/2000/02/000217083111.htm>.
Cold Spring Harbor Laboratory. (2000, February 17). Progress In Mental Retardation Research. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2000/02/000217083111.htm
Cold Spring Harbor Laboratory. "Progress In Mental Retardation Research." ScienceDaily. www.sciencedaily.com/releases/2000/02/000217083111.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins