Featured Research

from universities, journals, and other organizations

Progress In Mental Retardation Research

Date:
February 17, 2000
Source:
Cold Spring Harbor Laboratory
Summary:
A major rationale for genome sequencing is the promise of understanding human disorders, as articles in Genome Research often remind us. This month, in a report on recent progress in mental retardation (MR) research, Jozef Gécz and John Mulley (University of Adelaide) explain how advances in human genome sequencing have helped uncover genes involved in MR.

A major rationale for genome sequencing is the promise of understanding human disorders, as articles in Genome Research often remind us. This month, in a report on recent progress in mental retardation (MR) research, Jozef Gécz and John Mulley (University of Adelaide) explain how advances in human genome sequencing have helped uncover genes involved in MR.

Related Articles


Mental retardation, defined as IQ under 70, affects two to three percent of the population, either as part of a complex syndrome (e.g., Down syndrome) or by itself (non-specific MR). Many different gene defects can cause non-specific MR, including a variety of mutations on the X chromosome that mostly affect males. Because sufferers with different mutations can have similar symptoms, pinpointing individual genes for MR is difficult. In this review, Gécz and Mulley describe how sequence data and resources derived from the Human Genome Project have come together with traditional genetic studies to jumpstart research on non-specific mental retardation.

As a result, scientists have recently identified seven X-linked genes whose mutations cause non-specific MR, among an estimated 20-100 such genes on the X chromosome and possibly hundreds altogether on the human genome. Interestingly, most of the identified genes participate in intracellular signaling and are highly active in the hippocampus, a brain region involved in human memory. With the advent of new genomic technologies such as DNA arrays, say Gécz and Mulley, we might realistically hope to identify all genes involved in mental retardation. Such an achievement would illuminate not only the causes of mental retardation but also the workings of the healthy human brain.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Progress In Mental Retardation Research." ScienceDaily. ScienceDaily, 17 February 2000. <www.sciencedaily.com/releases/2000/02/000217083111.htm>.
Cold Spring Harbor Laboratory. (2000, February 17). Progress In Mental Retardation Research. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2000/02/000217083111.htm
Cold Spring Harbor Laboratory. "Progress In Mental Retardation Research." ScienceDaily. www.sciencedaily.com/releases/2000/02/000217083111.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) — Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) — AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins