Featured Research

from universities, journals, and other organizations

Progress In Mental Retardation Research

Date:
February 17, 2000
Source:
Cold Spring Harbor Laboratory
Summary:
A major rationale for genome sequencing is the promise of understanding human disorders, as articles in Genome Research often remind us. This month, in a report on recent progress in mental retardation (MR) research, Jozef Gécz and John Mulley (University of Adelaide) explain how advances in human genome sequencing have helped uncover genes involved in MR.

A major rationale for genome sequencing is the promise of understanding human disorders, as articles in Genome Research often remind us. This month, in a report on recent progress in mental retardation (MR) research, Jozef Gécz and John Mulley (University of Adelaide) explain how advances in human genome sequencing have helped uncover genes involved in MR.

Mental retardation, defined as IQ under 70, affects two to three percent of the population, either as part of a complex syndrome (e.g., Down syndrome) or by itself (non-specific MR). Many different gene defects can cause non-specific MR, including a variety of mutations on the X chromosome that mostly affect males. Because sufferers with different mutations can have similar symptoms, pinpointing individual genes for MR is difficult. In this review, Gécz and Mulley describe how sequence data and resources derived from the Human Genome Project have come together with traditional genetic studies to jumpstart research on non-specific mental retardation.

As a result, scientists have recently identified seven X-linked genes whose mutations cause non-specific MR, among an estimated 20-100 such genes on the X chromosome and possibly hundreds altogether on the human genome. Interestingly, most of the identified genes participate in intracellular signaling and are highly active in the hippocampus, a brain region involved in human memory. With the advent of new genomic technologies such as DNA arrays, say Gécz and Mulley, we might realistically hope to identify all genes involved in mental retardation. Such an achievement would illuminate not only the causes of mental retardation but also the workings of the healthy human brain.


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Progress In Mental Retardation Research." ScienceDaily. ScienceDaily, 17 February 2000. <www.sciencedaily.com/releases/2000/02/000217083111.htm>.
Cold Spring Harbor Laboratory. (2000, February 17). Progress In Mental Retardation Research. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2000/02/000217083111.htm
Cold Spring Harbor Laboratory. "Progress In Mental Retardation Research." ScienceDaily. www.sciencedaily.com/releases/2000/02/000217083111.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) — Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) — The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins