Featured Research

from universities, journals, and other organizations

Sick Kids’ Researchers Reverse Fatal Pulmonary Hypertension

Date:
May 31, 2000
Source:
The Hospital For Sick Children
Summary:
Research conducted at The Hospital for Sick Children (HSC) has opened up the possibility for a new treatment for pulmonary hypertension that may also be applicable to all types of blood vessel obstruction.

Research conducted at The Hospital for Sick Children (HSC) has opened up the possibility for a new treatment for pulmonary hypertension that may also be applicable to all types of blood vessel obstruction. This research is reported in the June issue of the scientific journal Nature Medicine.

Related Articles


Pulmonary hypertension results from obstruction of the blood vessels of the lung. It is a common complication of most heart and lung diseases, and it leads to heart failure. Pulmonary hypertension can also occur more rarely as a rapidly progressive and fatal condition that requires chronic intravenous therapy, or a lung or heart-lung transplant.

"We were able to completely reverse fatal pulmonary hypertension in an animal model using an elastase inhibitor. Not only did it stop the progression of the disease, but the blood vessel reverted to a normal condition," said Dr. Kyle Cowan, who carried out the study as a doctoral student under the supervision of Dr. Marlene Rabinovitch, head of the Cardiovascular Research program in HSC’s Research Institute.

Elastase is an enzyme that causes cells in blood vessels to rapidly divide, so that the vessel becomes obstructed. Dr. Rabinovitch’s laboratory used a synthetic, chemical compound (a serine elastase inhibitor) to induce the cells to die and the excess connective tissue to be reabsorbed, thus opening up the blood vessel.

"This research may lead to new avenues in the treatment of many cardiovascular conditions, including the serious problem of pulmonary hypertension. While this study deals with obstructed pulmonary arteries, a similar mechanism may be applicable in reversing coronary disease as well," said Dr. Rabinovitch, holder of the Heart and Stroke Foundation of Ontario Chair at The Hospital for Sick Children, recipient of the Medical Research Council of Canada Distinguished Scientist Award, and a Professor of Paediatrics, Laboratory Medicine and Pathobiology, and Medicine at the University of Toronto.

"Initially, we would like to try the use of an elastase inhibitor with patients who have pulmonary hypertension. The drug which we have tested on animals needs to be developed for clinical trials in humans."

This research was funded by the Heart and Stroke Foundation of Ontario, Medical Research Council of Canada, and the Primary Pulmonary Hypertension Cure Foundation.


Story Source:

The above story is based on materials provided by The Hospital For Sick Children. Note: Materials may be edited for content and length.


Cite This Page:

The Hospital For Sick Children. "Sick Kids’ Researchers Reverse Fatal Pulmonary Hypertension." ScienceDaily. ScienceDaily, 31 May 2000. <www.sciencedaily.com/releases/2000/05/000531071211.htm>.
The Hospital For Sick Children. (2000, May 31). Sick Kids’ Researchers Reverse Fatal Pulmonary Hypertension. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2000/05/000531071211.htm
The Hospital For Sick Children. "Sick Kids’ Researchers Reverse Fatal Pulmonary Hypertension." ScienceDaily. www.sciencedaily.com/releases/2000/05/000531071211.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins