Featured Research

from universities, journals, and other organizations

Drug Delivery System May Help Fight Osteoporosis

Date:
September 5, 2000
Source:
University Of Alberta
Summary:
A researcher at the University of Alberta has identified a way of delivering proteins directly to the bones that need them--a discovery which may lead to new ways of treating osteoporosis.

A researcher at the University of Alberta has identified a way of delivering proteins directly to the bones that need them--a discovery which may lead to new ways of treating osteoporosis.

Related Articles


"The whole idea is to keep the therapeutic agent at the needed site," said Dr. Hasan Uludag, a professor in biomedical engineering and the lead author on a paper appearing in the current issue of Biotechnology Progress. "So we had to build a mechanism that chemically links biomaterial to the chemically therapeutic agent. Our interfacial engineering is what makes the concept unique."

Most current osteoporosis drugs do not directly reach the targeted bone but end up deposited in other areas of the body, which can eventually cause muscle and kidney damage, said Uludag.

His team uses a novel way of keeping the drug at the desired site by blending proteins known as growth factors that stimulate the cells necessary for growth. The unique method means more than half of the carrier molecules go directly to the targeted bone, and the body eliminates the rest. When his team injected the drug into the leg bones of rats, the researchers found an eight to 12-fold higher retention of the protein than normally expected. It is the first time a vehicle to deliver the drug directly to bones has been identified.

"One challenge with bones is that fractures heal very slowly, especially in the elderly," he said. "And there are also between five to 10 per cent which don't heal at all. Doctors will often take bone grafts from other parts of the body and transfer them to the fractured parts. We are trying to eliminate the invasive work with our drug-delivery vehicle."

Uludag's project received support from the U of A's Faculty of Medicine and Dentistry Start-up Funds and the Medical Research Council of Canada (now known as the Canadian Institute for Health Research).

The U of A in Edmonton, Alberta is one of Canada's premier teaching and research universities serving more than 30,000 students with 6,000 faculty and staff. It continues to lead the country with the most 3M Teaching Fellows, Canada's only national award recognizing teaching excellence.


Story Source:

The above story is based on materials provided by University Of Alberta. Note: Materials may be edited for content and length.


Cite This Page:

University Of Alberta. "Drug Delivery System May Help Fight Osteoporosis." ScienceDaily. ScienceDaily, 5 September 2000. <www.sciencedaily.com/releases/2000/09/000904093148.htm>.
University Of Alberta. (2000, September 5). Drug Delivery System May Help Fight Osteoporosis. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2000/09/000904093148.htm
University Of Alberta. "Drug Delivery System May Help Fight Osteoporosis." ScienceDaily. www.sciencedaily.com/releases/2000/09/000904093148.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins