Featured Research

from universities, journals, and other organizations

University of Kentucky Researcher Discovers Drug That Shows Promise In Treating Rare Cancer

Date:
October 4, 2000
Source:
University Of Kentucky Medical Center
Summary:
New research published recently in the journal Thyroid shows that paclitaxel (Taxol®) has significant clinical activity against anaplastic thyroid carcinoma (ATC).

New research published recently in the journal Thyroid shows that paclitaxel (Taxol®) has significant clinical activity against anaplastic thyroid carcinoma (ATC). The research study was led by Kenneth B. Ain, M.D., associate professor, Division of Endocrinology, Department of Internal Medicine, University of Kentucky College of Medicine, and Medical Service at the Veterans Affairs Medical Center in Lexington.

This study is an example of how treatments can be developed from basic research through clinical trials in patients entirely by faculty at the UK Chandler Medical Center and the VAMC in Lexington.

Paclitaxel is a compound that was isolated from the bark of the Pacific yew tree. The U.S. Food and Drug Administration has approved paclitaxel to treat breast and ovarian cancer, non-small-cell lung cancer, and AIDS-related Kaposi's sarcoma.

ATC is a rare disease with no effective therapies. It is the most aggressive solid cancer and is always fatal, with a mean survival time after diagnosis of two to five months with treatment. ATC accounts for 1.6 percent of all thyroid cancers, and there are about 300 cases in the United States each year.

Ain created the thyroid cancer program at the UK Chandler Medical Center. Patients from around the world receive clinical care through the program.

The recently published study was a Phase II trial, or a clinical trial required for approval of a drug indication by the Food and Drug Administration that focuses on the effectiveness of a single drug. In the study, paclitaxel was infused continuously over 96 hours every three weeks for one to six treatments. Of the 19 evaluable patients, 53 percent showed a response to the drug, meaning their survival time increased. However, treatment with paclitaxel did not alter the mortality rate.

Ain's team currently is researching adding other drugs to paclitaxel in an effort to find more effective treatments for ATC.


Story Source:

The above story is based on materials provided by University Of Kentucky Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Kentucky Medical Center. "University of Kentucky Researcher Discovers Drug That Shows Promise In Treating Rare Cancer." ScienceDaily. ScienceDaily, 4 October 2000. <www.sciencedaily.com/releases/2000/09/000913205318.htm>.
University Of Kentucky Medical Center. (2000, October 4). University of Kentucky Researcher Discovers Drug That Shows Promise In Treating Rare Cancer. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2000/09/000913205318.htm
University Of Kentucky Medical Center. "University of Kentucky Researcher Discovers Drug That Shows Promise In Treating Rare Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/09/000913205318.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins