Featured Research

from universities, journals, and other organizations

Trauma And Stress In Early Life Increases Vulnerability To Cocaine Addiction In Adulthood, Yale Researchers Find

Date:
November 21, 2000
Source:
Yale University
Summary:
The trauma that a majority of drug addicts suffer in early life has now been shown to increase their vulnerability to drug addiction, Yale researchers report in a new study.

The trauma that a majority of drug addicts suffer in early life has now been shown to increase their vulnerability to drug addiction, Yale researchers report in a new study.

"Using well-established animal models, we’ve found strong evidence that early life stress enhances vulnerability to drug addiction," said Therese A. Kosten, assistant professor of psychiatry at Yale School of Medicine. "This study demonstrates the need to target drug abuse prevention strategies to children with early life traumas."

Rat pups that were separated from their mothers for one hour per day during the first week of life learned to self-administer cocaine more readily when they were adults compared to rats that had not had this early life stress. This effect was not due to differences in learning or general activity levels.

"Previous studies show that most drug addicts have had early life trauma," said Kosten, principal investigator on the study. "Given that 1.8 million Americans are currently using cocaine, this information will be valuable in directing future research toward potential interventions for children with early stress experiences in order to reduce the risk of developing drug addiction in adults."

Published in a recent issue of the journal Brain Research, Kosten and her team tested 14 adult rats, eight of which had experienced the stress of isolation from their mother, siblings and nest three months earlier. Compared to six rats that had not experienced this stress, isolated rats learned to press a lever to receive a cocaine infusion in two-thirds the number of days, and at half the dose needed for the non-isolated rats. Kosten said the groups did not differ in the number of days to learn to press a lever to receive food pellets, demonstrating that the isolation effect was specific to cocaine.

Kosten’s research team included Mindy J.D. Miserendino of Sacred Heart University and Priscilla Kehoe of Trinity College. The National Institute on Drug Abuse funded the study.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Trauma And Stress In Early Life Increases Vulnerability To Cocaine Addiction In Adulthood, Yale Researchers Find." ScienceDaily. ScienceDaily, 21 November 2000. <www.sciencedaily.com/releases/2000/11/001120073323.htm>.
Yale University. (2000, November 21). Trauma And Stress In Early Life Increases Vulnerability To Cocaine Addiction In Adulthood, Yale Researchers Find. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2000/11/001120073323.htm
Yale University. "Trauma And Stress In Early Life Increases Vulnerability To Cocaine Addiction In Adulthood, Yale Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2000/11/001120073323.htm (accessed August 22, 2014).

Share This




More Mind & Brain News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins