Featured Research

from universities, journals, and other organizations

Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke

Date:
November 29, 2000
Source:
Rush Presbyterian St. Luke's Medical Center
Summary:
Thanks to innovative magnetic resonance imaging technology (MRI), researchers at Rush-Presbyterian-St. Luke's Medical Center, Chicago may discover the reason why some people become demented after experiencing a stroke and others do not. Stroke is the third leading cause of death in the United States and is a leading cause of disability.

Thanks to innovative magnetic resonance imaging technology (MRI), researchers at Rush-Presbyterian-St. Luke's Medical Center, Chicago may discover the reason why some people become demented after experiencing a stroke and others do not. Stroke is the third leading cause of death in the United States and is a leading cause of disability. About 750,000 people in the U.S. suffer a stroke each year.

Rush physicians and researchers are enrolling 110 participants in a $3 million National Institutes of Health supported study to determine why 30 percent of those who experience a stroke have cognitive problems while the others are able to function more normally. Most strokes occur when a blood clot blocks an artery that carries oxygenated blood to the brain.

A new technology using quantitative MRI analysis as well as diffusion tensor imaging will help identify risk markers in the brain. The researchers are focusing on two areas: the hippocampus, which is the section of the brain responsible for short-term memory, and the entorhinal cortex, which takes in information to other parts of the brain, including the hippocampus.

Looking at special MRIs of these areas, Rush scientists will be able to tell whether these two key areas of the brain were deteriorating before the stroke occurred, providing a key glimpse into possible risk factors for stroke.

If the deterioration in the hippocampus or entorhinal cortex was present before stroke, it may serve as a warning sign that individuals are at greater risk for post-stroke dementia and Alzheimer's or other cognitive disorders.

"My hope is that this five-year study will refine our knowledge of mechanisms and causes for dementia in stroke patients so that we can improve our stroke prevention efforts," said Dr. Philip B. Gorelick, director of the Center for Stroke Research at Rush-Presbyterian-St. Luke's Medical Center and principal investigator for the study. "We may find that risk factors for diseases like stroke are also risk factors for Alzheimer's and be able to design preventive strategies for both."

The MRIs provide a detailed, snapshot of the white matter in the brain, said Gorelick. "This white matter, or myelin, acts like insulation does to wiring - when it is intact, it allows the axons, which are the channels that information flows through in the brain, to work properly. When the insulation, or white matter, gets frayed or damaged, the channels inside them cannot function as well, leading to possible cognitive impairment."

The MRI data will then be compared with information gathered from cognitive tests designed to assess thinking and memory. Genetic factors will also be examined, he said. When appropriate, autopsies will be used to verify collected data.

Diffusion tensor imaging, which was developed by scientists at Stanford University and shared with Rush, uses a pulsing technique to capture images of water molecules flowing through the brain's axons. These images show whether the water molecules are flowing in the proper direction which gives us a hint of whether the white matter is intact or not, said Rush neuroscientist "Using quantitative MRI analysis may provide us with important information concerning areas that are critical for cognitive dysfunction that are important for dementia in either stroke or Alzheimer's Diseases," said Rush neuroscientist Leyla deToledo Morrell, PhD. "This may allow us to specify which regions of the brain and provide us with markers we can correlate with functional tests to assess risk for these dementing diseases."


Story Source:

The above story is based on materials provided by Rush Presbyterian St. Luke's Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Rush Presbyterian St. Luke's Medical Center. "Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke." ScienceDaily. ScienceDaily, 29 November 2000. <www.sciencedaily.com/releases/2000/11/001129075920.htm>.
Rush Presbyterian St. Luke's Medical Center. (2000, November 29). Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2000/11/001129075920.htm
Rush Presbyterian St. Luke's Medical Center. "Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke." ScienceDaily. www.sciencedaily.com/releases/2000/11/001129075920.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins