Featured Research

from universities, journals, and other organizations

Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke

Date:
November 29, 2000
Source:
Rush Presbyterian St. Luke's Medical Center
Summary:
Thanks to innovative magnetic resonance imaging technology (MRI), researchers at Rush-Presbyterian-St. Luke's Medical Center, Chicago may discover the reason why some people become demented after experiencing a stroke and others do not. Stroke is the third leading cause of death in the United States and is a leading cause of disability.

Thanks to innovative magnetic resonance imaging technology (MRI), researchers at Rush-Presbyterian-St. Luke's Medical Center, Chicago may discover the reason why some people become demented after experiencing a stroke and others do not. Stroke is the third leading cause of death in the United States and is a leading cause of disability. About 750,000 people in the U.S. suffer a stroke each year.

Related Articles


Rush physicians and researchers are enrolling 110 participants in a $3 million National Institutes of Health supported study to determine why 30 percent of those who experience a stroke have cognitive problems while the others are able to function more normally. Most strokes occur when a blood clot blocks an artery that carries oxygenated blood to the brain.

A new technology using quantitative MRI analysis as well as diffusion tensor imaging will help identify risk markers in the brain. The researchers are focusing on two areas: the hippocampus, which is the section of the brain responsible for short-term memory, and the entorhinal cortex, which takes in information to other parts of the brain, including the hippocampus.

Looking at special MRIs of these areas, Rush scientists will be able to tell whether these two key areas of the brain were deteriorating before the stroke occurred, providing a key glimpse into possible risk factors for stroke.

If the deterioration in the hippocampus or entorhinal cortex was present before stroke, it may serve as a warning sign that individuals are at greater risk for post-stroke dementia and Alzheimer's or other cognitive disorders.

"My hope is that this five-year study will refine our knowledge of mechanisms and causes for dementia in stroke patients so that we can improve our stroke prevention efforts," said Dr. Philip B. Gorelick, director of the Center for Stroke Research at Rush-Presbyterian-St. Luke's Medical Center and principal investigator for the study. "We may find that risk factors for diseases like stroke are also risk factors for Alzheimer's and be able to design preventive strategies for both."

The MRIs provide a detailed, snapshot of the white matter in the brain, said Gorelick. "This white matter, or myelin, acts like insulation does to wiring - when it is intact, it allows the axons, which are the channels that information flows through in the brain, to work properly. When the insulation, or white matter, gets frayed or damaged, the channels inside them cannot function as well, leading to possible cognitive impairment."

The MRI data will then be compared with information gathered from cognitive tests designed to assess thinking and memory. Genetic factors will also be examined, he said. When appropriate, autopsies will be used to verify collected data.

Diffusion tensor imaging, which was developed by scientists at Stanford University and shared with Rush, uses a pulsing technique to capture images of water molecules flowing through the brain's axons. These images show whether the water molecules are flowing in the proper direction which gives us a hint of whether the white matter is intact or not, said Rush neuroscientist "Using quantitative MRI analysis may provide us with important information concerning areas that are critical for cognitive dysfunction that are important for dementia in either stroke or Alzheimer's Diseases," said Rush neuroscientist Leyla deToledo Morrell, PhD. "This may allow us to specify which regions of the brain and provide us with markers we can correlate with functional tests to assess risk for these dementing diseases."


Story Source:

The above story is based on materials provided by Rush Presbyterian St. Luke's Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Rush Presbyterian St. Luke's Medical Center. "Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke." ScienceDaily. ScienceDaily, 29 November 2000. <www.sciencedaily.com/releases/2000/11/001129075920.htm>.
Rush Presbyterian St. Luke's Medical Center. (2000, November 29). Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2000/11/001129075920.htm
Rush Presbyterian St. Luke's Medical Center. "Researchers Use Unique Imaging Technology To Study Changes In The Brain That Lead To Dementia Following Stroke." ScienceDaily. www.sciencedaily.com/releases/2000/11/001129075920.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) — More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Weird Things Couples Do When They Lose Their Phone

Weird Things Couples Do When They Lose Their Phone

BuzzFeed (Jan. 24, 2015) — Did you back it up? Do you even know how to do that? Video provided by BuzzFeed
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
Amazing Technology Allows Blind Mother to See Her Newborn Son

Amazing Technology Allows Blind Mother to See Her Newborn Son

RightThisMinute (Jan. 23, 2015) — Not only is Kathy seeing her newborn son for the first time, but this is actually the first time she has ever seen a baby. Kathy and her sister, Yvonne, have been legally blind since childhood, but thanks to an amazing new technology, eSight glasses, which gives those who are legally blind the ability to see, she got the chance to see the birth of her son. It&apos;s an incredible moment and an even better story. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins