Featured Research

from universities, journals, and other organizations

Insulin-Like Hormone Helps Prevent Heart Muscle Death, Could Lead To Gene Therapies For Diabetes, Heart Disease

Date:
December 25, 2000
Source:
University Of California, Irvine
Summary:
A hormone similar to insulin prevents heart muscle from dying by initiating a series of cellular biochemical interactions, a UC Irvine College of Medicine research team has found.

Irvine, Calif., Wed., Dec. 20, 2000 -- A hormone similar to insulin prevents heart muscle from dying by initiating a series of cellular biochemical interactions, a UC Irvine College of Medicine research team has found.

The findings--the first to provide a detailed picture of the link between this insulin-related hormone and heart muscle death--suggest that gene therapy might help treat a variety of heart diseases, as well as stave off heart damage that is common among diabetes patients. The study appears in the Dec. 22 issue of the Journal of Biological Chemistry.

Dr. Ping Wang, associate professor of medicine and biological chemistry, and his colleagues found that the hormone, called IGF-1 (insulin-like growth factor), kept heart muscle cells from dying by suppressing the activation of assassinator molecules that trigger cell death. The study suggests that inserting genes for the chemicals mediating IGF-1 actions could help reverse the heart muscle cell death that ultimately leads to heart failure.

"We've recently shown that circulating IGF-1 levels correlate with patient prognosis after heart attack. People with low levels of IGF-1 who had heart attacks had poorer recovery rates than heart attack victims with higher levels of the growth factor," Wang said. "This study helps us elucidate the biochemical interactions that help us further understand how IGF-1 and insulin protect heart muscle, and how we might find an effective way to enhance heart muscle survival in diabetes and in heart diseases."

The researchers found that an enzyme called PI-3 kinase mimics IGF-1's ability to inhibit the death of heart muscle cells. In cells that had genetically engineered PI-3 kinase, the activities of cell-killing molecules that trigger cell death (a process known as apoptosis) were greatly reduced, as was fragmentation of DNA from the muscle cells that occurs as cells undergo apoptosis.

The study provides more details of a biochemical pathway--consisting of IGF-1, receptors for IGF-1 on the surface of muscle cells and PI-3 kinase--that plays a major role in controlling the survival of heart muscle cells. While normal apoptosis reduces harm to the body by eliminating deteriorating cells, abnormally high rates of apoptosis can cause disease (such as the cardiac complications of diabetes) by killing more healthy cells. The scientists think that inserting genes that encourage the activation of the cell-protecting PI-3 kinase might increase heart survival after a heart attack and reduce the cardiac complications from diabetes.

"IGF-1 is structurally similar to insulin; both hormones cross-react to each others' cell surface receptors, triggering similar effects as insulin alone," Wang said. "Since we normally see increased heart muscle apoptosis in diabetes as well as other heart diseases, we think this pathway may help us develop a form of gene therapy. To do this, we first need to detail how this and other pathways regulate apoptosis in these cells."

The researchers are now working on genetically manipulating IGF-1 and signaling proteins within cells that activate it to reduce heart muscle cell death.

Wang's team was supported by grants from the National Heart, Lung and Blood Institute, the American Heart Association and the American Diabetes Association. Wang's colleagues in the study included Weihua Wu, Wen Lieng Lee, Yvonne Y. Wu, Daniel Chen, Tsun-jui Liu and Andy Jang of UCI and Prem Sharma of UC San Diego.


Story Source:

The above story is based on materials provided by University Of California, Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, Irvine. "Insulin-Like Hormone Helps Prevent Heart Muscle Death, Could Lead To Gene Therapies For Diabetes, Heart Disease." ScienceDaily. ScienceDaily, 25 December 2000. <www.sciencedaily.com/releases/2000/12/001225062149.htm>.
University Of California, Irvine. (2000, December 25). Insulin-Like Hormone Helps Prevent Heart Muscle Death, Could Lead To Gene Therapies For Diabetes, Heart Disease. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2000/12/001225062149.htm
University Of California, Irvine. "Insulin-Like Hormone Helps Prevent Heart Muscle Death, Could Lead To Gene Therapies For Diabetes, Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2000/12/001225062149.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins