Featured Research

from universities, journals, and other organizations

Maryland Researchers Find Anti-Fever Drugs May Prolong Flu

Date:
December 29, 2000
Source:
University Of Maryland Baltimore
Summary:
Researchers at the University of Maryland schools of medicine and pharmacy found that anti-fever drugs such as aspirin and acetaminophen may prolong influenza A infections. The study results were released in the December 2000 issue of Pharmacotherapy, the official journal of the American College of Clinical Pharmacy.

Researchers at the University of Maryland schools of medicine and pharmacy found that anti-fever drugs such as aspirin and acetaminophen may prolong influenza A infections. The study results were released in the December 2000 issue of Pharmacotherapy, the official journal of the American College of Clinical Pharmacy.

In a series of vaccine studies conducted between 1978 and 1987 at the University's Center for Vaccine Development, 54 volunteers were injected with Influenza A, 45 with S. sonnei, and 21 with R. rickettsii. During these studies, some of the subjects were given aspirin or acetaminophen for relief of symptoms such as fever. The current study compared the duration of illness in those who received the medication with those who did not.

"The analysis suggests that anti-fever therapy prolonged illness in subjects infected with Influenza A, but not shigellosis or Rocky Mountain spotted fever," says Philip A. Mackowiak, MD, one of the study's principal investigators and chief of the Medical Care Clinical Center, V.A. Maryland Health Care System and professor at the School of Medicine.

"Our research suggests that fever may have different roles in the resolution of bacterial and viral infections," says Karen I. Plaisance, PharmD, associate professor at the School of Pharmacy, the study's other lead investigator.

"The original studies weren't designed to look at anti-fever drugs," says Mackowiak. "They were designed to study the potency of several experimental vaccines. We examined the study after the fact to determine to impact of anti-fever drugs on the outcomes of infections."

Study results indicate that participants infected with Influenza A- and S. sonnei had the illness of a longer duration, but also higher maximum temperatures during this illness, and more symptoms of infection on the day of the maximum temperature.

"These findings suggest that anti-fever drugs might have been associated with prolonged illness simply because aspirin and acetaminophen were given to the sickest subjects. But an analysis of the relationship between the duration of the illness and the antipyretic therapy was considered along with several other clinical and demographic variables, and only those who were administered the drugs exhibited a statistically significant relationship with the duration of the illness in influenza A and S. sonnei-infected patients," says Mackowiak.

According to Mackowiak, further analysis suggested that anti-fever drugs caused influenza A to be prolonged but were more likely the result of prolonged illness in subjects injected with S. sonnei; in the former instance they were administered early in the course of the illness, and in the latter, late in the course of the illness.

In short, says Mackowiak, "the good news is that anti-fever drugs make people feel better when they have infections. The bad news is that they may cause the illness to linger longer. It doesn't mean people shouldn't take anti-fever drugs. It means that they should be aware that anti-fever drugs have a modest cost associated with relief and that cost is that they may be sick longer."


Story Source:

The above story is based on materials provided by University Of Maryland Baltimore. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Baltimore. "Maryland Researchers Find Anti-Fever Drugs May Prolong Flu." ScienceDaily. ScienceDaily, 29 December 2000. <www.sciencedaily.com/releases/2000/12/001228090125.htm>.
University Of Maryland Baltimore. (2000, December 29). Maryland Researchers Find Anti-Fever Drugs May Prolong Flu. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2000/12/001228090125.htm
University Of Maryland Baltimore. "Maryland Researchers Find Anti-Fever Drugs May Prolong Flu." ScienceDaily. www.sciencedaily.com/releases/2000/12/001228090125.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins