Featured Research

from universities, journals, and other organizations

Researcher Uncovers Allergy/Reflux Link

Date:
December 29, 2000
Source:
Children's Hospital Medical Center Of Cincinnati
Summary:
A new Children's Hospital Medical Center of Cincinnati discovery may have significant implications for children with a eosinophilic esophagitis, a fast-growing new disease whose symptoms mimic gastroesophageal reflux, and for adults with reflux who are not being helped by currently available medications.

A new Children's Hospital Medical Center of Cincinnati discovery may have significant implications for children with a eosinophilic esophagitis, a fast-growing new disease whose symptoms mimic gastroesophageal reflux, and for adults with reflux who are not being helped by currently available medications.

Related Articles


In a study published in the January issue of The Journal of Clinical Investigation, Marc E. Rothenberg, M.D., Ph.D., has established a link between reflux and allergy - not only food allergies but also environmental allergens such as pollens and molds. Dr. Rothenberg, the study's senior author, and his colleague Anil Mishra, Ph.D., have developed the first experimental system, a mouse model, for eosinophilic esophagitis - a disease whose numbers have exploded in recent years.

"We're saying that what a person breathes in can actually affect the gastrointestinal system," says Dr. Rothenberg, who directs the section of allergy and clinical immunology in Cincinnati Children's division of Pulmonary Medicine, Allergy and Clinical Immunology. "There is a direct link between exposure to allergens that go to the lung -- aeroallergens -- and development of esophageal inflammation."

Moreover, Dr. Rothenberg has discovered that this pathway is mediated by a molecule called interleukin-5. When Dr. Rothenberg's research group gave mice an allergen that induced asthma, all the mice developed esophagitis. But none of the mice deficient in IL-5 who were given the allergen developed esophagitis. "They were completely protected," says Dr. Mishra, Ph.D., a research associate in Dr. Rothenberg's lab and the study's lead author.

"Two major pharmaceutical companies have an antibody in human trials that blocks IL-5," adds Dr. Rothenberg. "These drugs are being tried for asthma, but based on our findings I'd like to see IL-5 blockers tried in patients with eosinophilic esophagitis."

Children with eosinophilic esophagitis often have abdominal pain, difficulty swallowing, vomiting, failure to thrive and weight loss. Just a few years ago, incidents of the disease were rare. Now, Dr. Rothenberg and his colleagues at Cincinnati Children's food allergy clinic treat about 60 cases each year. Physicians throughout the United States also report an explosion in the number of cases.

Adults with reflux have some similar symptoms. While many are helped by currently available medications, there is a significant subset that, like children with esophagitis, is not helped. Dr. Rothenberg believes that "a significant number of those may have an allergen-driven process; they have a different form of reflux that we're calling eosinophilic esophagitis."

Dr. Rothenberg derives the name from the fact that when patients came to Cincinnati Children's with esophagitis, biopsy showed a large infiltration of eosinophils, a type of white blood cell not normally seen in the esophagus, into the gastrointestinal tract. Eosinophils in tissue are also a hallmark feature of an allergic response.

The assocations between eosinophils and esophagitis and eosinophils and reflux have been previously reported, but Dr. Rothenberg noticed that many children in allergy clinic had gastrointestinal complaints. "When you skin test patients with eosinophilic esophagitis, 80 percent have allergies," he says, "not only food allergies but also environmental aeroallergens. This suggested that allergies may be a cause for the esophagitis."

"One of the things that struck me," adds Dr. Rothenberg, "is that we know that people who develop reflux often have asthma. There seems to be some link between the two. In fact, when those with asthma are treated for reflux they sometimes get better. Based on this clinical observation, and with the hunch that there was likely to be an association between the development of allergy and esophagitis, our research group subsequently developed the mouse model to prove it."

The results, which shed new light on a possible cause of esophagitis, suggest that therapy should be directed at controlling allergies and preventing exposure to environmental allergens.


Story Source:

The above story is based on materials provided by Children's Hospital Medical Center Of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital Medical Center Of Cincinnati. "Researcher Uncovers Allergy/Reflux Link." ScienceDaily. ScienceDaily, 29 December 2000. <www.sciencedaily.com/releases/2000/12/001229084502.htm>.
Children's Hospital Medical Center Of Cincinnati. (2000, December 29). Researcher Uncovers Allergy/Reflux Link. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2000/12/001229084502.htm
Children's Hospital Medical Center Of Cincinnati. "Researcher Uncovers Allergy/Reflux Link." ScienceDaily. www.sciencedaily.com/releases/2000/12/001229084502.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins