Featured Research

from universities, journals, and other organizations

Scientists Comment On Drafts Of Human Genome, Explain Applications

Date:
February 14, 2001
Source:
Harvard Medical School
Summary:
In a special issue of Nature, dated February 15, 2001, but published online Monday, February 12, Harvard Medical School researchers and other scientists around the world explain the latest findings, challenges, and applications of the Human Genome Project.

In a special issue of Nature, dated February 15, 2001, but published online Monday, February 12, Harvard Medical School researchers and other scientists around the world explain the latest findings, challenges, and applications of the Human Genome Project. Below is a description of three papers by Harvard medical faculty based at the school and at Massachusetts General Hospital and Brigham and Women's Hospital.

Paper Comparison of Public and Private Draft Sequences of the Human Genome

George Church and his colleagues have compared the draft sequences of the human genome, one produced by the publicly funded Human Genome Project and the other by Celera Genomics, which are the main topic of the special human genome issue of Nature and the corresponding issue of Science. The researchers found that, overall, the two sequences are very similar. Both are about the same size; both show about the same number of unique 15-base stretches; and both show very similar numbers of candidate binding sites for the two DNA binding proteins the team considered. The researchers did see differences in the distribution of sequence gaps that corresponded to the different strategies the two teams used for sequence assembly. At a detailed level, they also found one instance where the sequences were assembled in different ways. (Church and colleagues could not determine which, if either, of the two different assemblies was correct, and they believe that the sequencing teams themselves will be tracking and working through differences at this level.)

The article was written on the invitation and urging of Nature editors, who wanted to present a comparison of the two draft genome sequences. They contacted George Church, professor of genetics and Harvard Medical School, as a knowledgeable player in the field of sequencing who was part of neither gene mapping team, and who was therefore able to give an informed and independent assessment.

Church and his colleagues performed a small number of computational analyses that could be applied in parallel on the two draft sequences and compared the results. Some of these analyses-especially the comparisons of gap sizes in the sequences-aimed directly at comparing attributes of the two draft sequences. Others were chosen because the researchers believed they represented the kinds of analysis that others would perform regularly on complete human genome sequences. In this latter category were an analysis of 15-base stretches that are unique in the sequences and a search for candidate binding sites of selected DNA binding proteins.

Authors: George Church, professor of genetics at Harvard Medical School. John Aach, lecturer on genetics at Harvard Medical School.

Paper: Keeping Time with the Human Genome

Our understanding of the mammalian circadian clock has steadily increased through the cloning and characterization of its related gene family. By analyzing the new genome data, Steven Reppert and his research team have identified additional relatives in the 'clock gene' family that may further define our knowledge of the molecular workings of the circadian clock. This knowledge could lead to the development of therapies for sleep and neuropsychiatric disorders.

Authors: Steven Reppert, professor of pediatrics at Massachusetts General Hospital and Harvard Medical School.

Paper: Integration of Cytogenetic Landmarks into the Draft Sequence of the Human Genome

The paper addresses an important experimental problem: How do we tie the new DNA sequence map to other positional genetic maps like the chromosome structure (cytogenetic) map? In this paper, members of a research consortium mapped more than 7,500 large segments of DNA from three standard positional genetic maps to the new DNA sequence map. This integrated map is a very powerful tool for rapid localization of chromosome rearrangement breakpoints and discovery of corresponding disease genes. The Developmental Genome Anatomy Project (the Harvard extension of the consortium) provides an example of how this strategy will work in our search to find genes important in human development and congenital anomalies.

Authors: Bradley Quade, assistant professor of pathology at Brigham and Women's Hospital and Harvard Medical School.


Story Source:

The above story is based on materials provided by Harvard Medical School. Note: Materials may be edited for content and length.


Cite This Page:

Harvard Medical School. "Scientists Comment On Drafts Of Human Genome, Explain Applications." ScienceDaily. ScienceDaily, 14 February 2001. <www.sciencedaily.com/releases/2001/02/010214074157.htm>.
Harvard Medical School. (2001, February 14). Scientists Comment On Drafts Of Human Genome, Explain Applications. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2001/02/010214074157.htm
Harvard Medical School. "Scientists Comment On Drafts Of Human Genome, Explain Applications." ScienceDaily. www.sciencedaily.com/releases/2001/02/010214074157.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins