Featured Research

from universities, journals, and other organizations

Heart Disease Gene Discovery Strengthens Skeletal Disease Link

Date:
March 6, 2001
Source:
Baylor College Of Medicine
Summary:
A fourth gene associated with heart muscle disease that also has a link to skeletal and muscle disorders has been identified by researchers at Baylor College of Medicine.

HOUSTON (March 6, 2001) -- A fourth gene associated with heart muscle disease that also has a link to skeletal and muscle disorders has been identified by researchers at Baylor College of Medicine.

The latest discovery by Dr. Jeffrey A. Towbin, a professor of pediatric cardiology at Baylor, and his research team is reported in the March 6 issue of the journal Circulation. It identifies alpha-dystrobrevin, a cytoskeletal protein, in left ventricular disease. The research also confirms that mutations in the gene G4.5 result in a wide spectrum of heart muscle disease.

"If you have muscle disease, you have muscle disease," Towbin said. "It's intriguing that all of the cardiomyopathy genes lead to skeletal myopathy as well."

In identifying genes associated with structural heart disease, or cardiomyopathy, the Baylor team is focusing on finding the "final common pathway" that links heart muscle disease. Towbin said it is important for physicians to recognize the connection between structural heart disease and skeletal and muscle disorders. "There's this big picture that cardiologists, neurologists, general practitioners, family doctors and pediatricians all need to understand," he said.

For example, based on this link between muscle and heart disease, patients with muscular dystrophy should be screened early for heart disease. In the past, muscular dystrophy patients often were sent to a cardiologist after their heart disease had developed to a point where treatment was limited, said Towbin, who also serves as associate chief of pediatric cardiology at Texas Children's Hospital.

"If we can intervene early, before the patient has significant disease and essentially no symptoms, we can support the heart muscle for an extended period of time," he said.

Towbin said each of these gene discoveries is adding to the understanding that heart disease is associated with a complex interaction of proteins.

"In cardiac disease, it's not one gene and one protein that causes the problem. It's many proteins and genes and in most cases, the gene mutations are specific to the individual," he said. "Your mutation is not likely to be the same as anyone else's, except those in your family."

These findings will lead to better patient care, Towbin said, both through new targeted therapies and early intervention when heart muscle disease can be anticipated.

Other members of the research team included Fukiko Ichida, Shinichi Tsubata, Karla R. Bowles, Noriyuki Haneda, Keiichiro Uese, Toshio Miyawaki, W. Jeffrey Dreyer, John Messina, Hua Li and Neil E. Bowles.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Heart Disease Gene Discovery Strengthens Skeletal Disease Link." ScienceDaily. ScienceDaily, 6 March 2001. <www.sciencedaily.com/releases/2001/03/010306072438.htm>.
Baylor College Of Medicine. (2001, March 6). Heart Disease Gene Discovery Strengthens Skeletal Disease Link. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2001/03/010306072438.htm
Baylor College Of Medicine. "Heart Disease Gene Discovery Strengthens Skeletal Disease Link." ScienceDaily. www.sciencedaily.com/releases/2001/03/010306072438.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins