Featured Research

from universities, journals, and other organizations

Heart Disease Gene Discovery Strengthens Skeletal Disease Link

Date:
March 6, 2001
Source:
Baylor College Of Medicine
Summary:
A fourth gene associated with heart muscle disease that also has a link to skeletal and muscle disorders has been identified by researchers at Baylor College of Medicine.

HOUSTON (March 6, 2001) -- A fourth gene associated with heart muscle disease that also has a link to skeletal and muscle disorders has been identified by researchers at Baylor College of Medicine.

The latest discovery by Dr. Jeffrey A. Towbin, a professor of pediatric cardiology at Baylor, and his research team is reported in the March 6 issue of the journal Circulation. It identifies alpha-dystrobrevin, a cytoskeletal protein, in left ventricular disease. The research also confirms that mutations in the gene G4.5 result in a wide spectrum of heart muscle disease.

"If you have muscle disease, you have muscle disease," Towbin said. "It's intriguing that all of the cardiomyopathy genes lead to skeletal myopathy as well."

In identifying genes associated with structural heart disease, or cardiomyopathy, the Baylor team is focusing on finding the "final common pathway" that links heart muscle disease. Towbin said it is important for physicians to recognize the connection between structural heart disease and skeletal and muscle disorders. "There's this big picture that cardiologists, neurologists, general practitioners, family doctors and pediatricians all need to understand," he said.

For example, based on this link between muscle and heart disease, patients with muscular dystrophy should be screened early for heart disease. In the past, muscular dystrophy patients often were sent to a cardiologist after their heart disease had developed to a point where treatment was limited, said Towbin, who also serves as associate chief of pediatric cardiology at Texas Children's Hospital.

"If we can intervene early, before the patient has significant disease and essentially no symptoms, we can support the heart muscle for an extended period of time," he said.

Towbin said each of these gene discoveries is adding to the understanding that heart disease is associated with a complex interaction of proteins.

"In cardiac disease, it's not one gene and one protein that causes the problem. It's many proteins and genes and in most cases, the gene mutations are specific to the individual," he said. "Your mutation is not likely to be the same as anyone else's, except those in your family."

These findings will lead to better patient care, Towbin said, both through new targeted therapies and early intervention when heart muscle disease can be anticipated.

Other members of the research team included Fukiko Ichida, Shinichi Tsubata, Karla R. Bowles, Noriyuki Haneda, Keiichiro Uese, Toshio Miyawaki, W. Jeffrey Dreyer, John Messina, Hua Li and Neil E. Bowles.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Heart Disease Gene Discovery Strengthens Skeletal Disease Link." ScienceDaily. ScienceDaily, 6 March 2001. <www.sciencedaily.com/releases/2001/03/010306072438.htm>.
Baylor College Of Medicine. (2001, March 6). Heart Disease Gene Discovery Strengthens Skeletal Disease Link. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2001/03/010306072438.htm
Baylor College Of Medicine. "Heart Disease Gene Discovery Strengthens Skeletal Disease Link." ScienceDaily. www.sciencedaily.com/releases/2001/03/010306072438.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins