Scientists have found that an enzyme called Cdk5 regulates the action of chronic cocaine in the brain. In a paper published in the March Nature, members of Paul Greengard's Laboratory of Molecular and Cellular Neuroscience and colleagues at other institutions identify Cdk5's role in the long-term changes associated with cocaine addiction. By combining behavioral and biochemical studies, they found that Cdk5 (which stands for cyclin-dependent kinase 5) is a key player in a series of biochemical events that occur in certain brain cells with exposure to chronic cocaine.
The above story is based on materials provided by Rockefeller University. Note: Materials may be edited for content and length.
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