Featured Research

from universities, journals, and other organizations

Researchers Determine That MS And Diabetes Are Closely Linked Diseases

Date:
March 22, 2001
Source:
The Hospital For Sick Children
Summary:
A team of researchers led by Hospital for Sick Children (HSC) senior scientist Michael Dosch has determined that multiple sclerosis and type I (juvenile) diabetes mellitus are far more closely linked than previously thought, including the role cow milk protein plays as a risk factor in the development of both diseases for people who are genetically susceptible.

Toronto, March 20, 2001 - A team of researchers led by Hospital for Sick Children (HSC) senior scientist Michael Dosch has determined that multiple sclerosis and type I (juvenile) diabetes mellitus are far more closely linked than previously thought, including the role cow milk protein plays as a risk factor in the development of both diseases for people who are genetically susceptible. This research is published in recent issues of The Journal of Immunology (April 1 and February 15, 2001).

Multiple sclerosis (MS) and type I diabetes mellitus are autoimmune disorders, where the body's immune system attacks its own tissue. The diseases are entirely different clinically, but have nearly identical ethnic and geographic distribution, genetic similarities, and, as is now known, shared environmental risk factors.

In a collaboration between The Hospital For Sick Children, St. Michael's Hospital and the Pittsburgh Children's Hospital, Dr. Dosch's laboratory discovered a high degree of similarity in the autoimmunity of MS and diabetes patients, and that a widely used mouse model for diabetes could also develop an MS-like disease.

"Much to our surprise, we found that immunologically, type I diabetes and multiple sclerosis are almost the same - in a test tube you can barely tell the two diseases apart," said Dr. Dosch, the study's principal investigator, a senior scientist in the HSC Research Institute, and a professor of Paediatrics and Immunology at the University of Toronto (U of T). "We found that the autoimmunity was not specific to the organ system affected by the disease. Previously it was thought that in MS autoimmunity would develop in the central nervous system, and in diabetes it would only be found in the pancreas. We found that both tissues are targeted in each disease."

In diabetes and MS, there is a long, drawn-out period of silent disease years before the appearance of symptoms and diagnosis of the disease. In diabetes, it is this "pre-diabetes" phase that is targeted by interventions to stop the development of the full-blown disease. Similar efforts are planned for individuals at high risk for MS.

"We are planning a large international study with centres in Canada and the US to test the possibility of interventions during the pre-MS phase," added Dr. Dosch.

One of the major environmental risk factors for diabetes is exposure to cow milk protein. Based on the role of cow milk protein as a risk factor in the development of type I diabetes, an international global diabetes prevention trial called TRIGR - Trial to Reduce Insulin-dependent diabetes in the Genetically at Risk - is expected to begin later this year, with Dr. Dosch as the trial's basic science chair. In the first step to test just how far the similarities between MS and diabetes go, the study's researchers looked for signs of abnormal immunity to cow milk in MS patients. Such abnormalities were indeed found in most patients, suggesting that similar processes may contribute to both diseases. If confirmed in a larger and prospective family study, it may become possible to design dietary means to influence the course of MS as well as diabetes.

"The similarities found between MS and type I diabetes will open new avenues of research. Our next focus will be to study MS family members for signs of early MS," said Dr. Paul O'Connor, head of the MS clinic at St. Michael's Hospital, a co-author of the study and Associate Professor of Neurology at U of T.

###Other collaborators on this research were: Shawn Winer, Igor Astsaturov, Roy K. Cheung, Lakshman Gunaratnam, Denise D. Wood and Professor Mario Moscarello, all from the HSC Research Institute; Colin McKerlie, Sunnybrook and Women's Health Sciences Centre and the University of Toronto; and Professor Dorothy J. Becker, Children's Hospital of Pittsburgh and the University of Pittsburgh.

Funding for this research was provided by the Canadian Institutes of Health Research, the Juvenile Diabetes Foundation, the Canadian Diabetes Association, the US National Institutes of Health and the Renziehausen Fund.


Story Source:

The above story is based on materials provided by The Hospital For Sick Children. Note: Materials may be edited for content and length.


Cite This Page:

The Hospital For Sick Children. "Researchers Determine That MS And Diabetes Are Closely Linked Diseases." ScienceDaily. ScienceDaily, 22 March 2001. <www.sciencedaily.com/releases/2001/03/010322074643.htm>.
The Hospital For Sick Children. (2001, March 22). Researchers Determine That MS And Diabetes Are Closely Linked Diseases. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2001/03/010322074643.htm
The Hospital For Sick Children. "Researchers Determine That MS And Diabetes Are Closely Linked Diseases." ScienceDaily. www.sciencedaily.com/releases/2001/03/010322074643.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins