Apr. 13, 2001 A 21-year-old junior at Johns Hopkins is building computer models that mimic electrical activity in the heart, showing patterns that can have fatal consequences. When Alok Sathaye's models are perfected, they may help researchers who are studying abnormal rhythms in the heart and looking for ways to prevent this dangerous condition.
Sathaye, whose work was supported by an undergraduate research grant from the university, is a 1998 graduate of Governor Livingston High School in Berkeley Heights, N.J. Early last year, he asked Leslie Tung, an associate professor of biomedical engineering, about research opportunities in Tung's Cardiac Bioelectric Systems Laboratory. Because Sathaye had a strong background in computer programming, Tung invited him to work on digital models that demonstrate how waves of electricity move though cardiac cells, causing the heart to beat. Emilia Entcheva, a postdoctoral fellow in the lab, provided additional support for the project. "I knew a lot about programming," Sathaye said, "but she helped me with the biology and the mathematics behind this type of computer modeling."
"Computer models are an important and valuable complement to experiments on living cardiac cells," said Tung, who sponsored Sathaye's grant application. "They can also allow us to study the underlying electrical behavior in much greater detail than we can do with living cells."
A reliable computer model enables scientists to easily see what happens when electrical activity in the heart is stimulated or disrupted. As part of his project, Sathaye has created animated sequences that show some electrical problems that can occur in a layer of cardiac cells. "If you have scar tissue from a heart attack, the electrical propagation of the heart changes," he said. "Instead of having an electrical wave go through the heart as it normally does, the wave circulates around the area of dead cells and can enter into a pattern of self-sustained, erratic activity." This abnormal rhythm can lead to cardiac arrest, he said.
Having completed his computer model of cardiac activity, Sathaye is now comparing his simulation results against tests conducted earlier in the Tung lab with engineered networks of living cells. "A computer model that can't be verified isn't very useful," he said. The Johns Hopkins junior, who is majoring in biomedical engineering and computer engineering, hopes to submit his work to a scholarly journal by the end of 2001. "This has been a real growth experience for me," he said.
As one of 43 Johns Hopkins students who received a Provost's Undergraduate Research Award in the 2000-2001 academic year, Sathaye will present an overview of his project during upcoming awards ceremony.
The Johns Hopkins University is recognized as the country's first graduate research university, and has been in recent years the leader among the nation's research universities in winning federal research and development grants.
The opportunity to be involved in important research is one of the distinguishing characteristics of an undergraduate education at Johns Hopkins. About 80 percent of the university's undergraduates engage in some form of independent research during their four years, most often alongside top researchers in their fields.
The Provost's Undergraduate Research Awards is one of these research opportunities, open to students in each of the university's four schools with full- time undergraduates: the Krieger School of Arts and Sciences, the G.W.C. Whiting School of Engineering, the Peabody Conservatory and the School of Nursing. Since 1993, about 40 students each year have been awarded up to $2,500 to propose and conduct original research, some results of which have been published in professional journals. The awards, begun by then provost Joseph Cooper and funded through a donation from the Hodson Trust, are an important part of the university's commitment to research.
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