Featured Research

from universities, journals, and other organizations

Laboratory Study Shows Measles Vaccine May Offer Novel Approach For Treating Lymphoma

Date:
June 12, 2001
Source:
Mayo Clinic
Summary:
The virus strain used worldwide for more than 30 years to produce the measles vaccine may be effective for another purpose — fighting lymphoma, a group of cancers that originate in the lymphatic system.

ROCHESTER, MINN. — The virus strain used worldwide for more than 30 years to produce the measles vaccine may be effective for another purpose — fighting lymphoma, a group of cancers that originate in the lymphatic system.

Related Articles


Scientists with Mayo Clinic’s molecular medicine program have found that the measles vaccine virus caused remission of lymphoma in mice injected with human cells containing the cancer. The findings from the study are published in the June 15 issue of Blood, Journal of the American Society of Hematology.

This laboratory study is thought to be the first research conducted by any medical research institution to demonstrate the destructive effects of the measles vaccine virus on lymphoma cells. It is one of several research studies underway at Mayo Clinic to investigate the effects of the measles vaccine virus on cancer.

Adele Fielding, M.D., Ph.D., lead researcher on the newly-published Mayo Clinic study, describes the findings as an early step in potentially developing the measles vaccine virus into a treatment for patients with advanced lymphomas.

"Our research involved the use of derivatives of the Edmonston-B strain of the measles vaccine to study its effects on both aggressive and slow-growing B-cell lymphoma," says Dr. Fielding.

"We found that injecting the vaccine strain of the virus into the tumor caused remission of the large, established human B-cell lymphoma in laboratory mice with the cancer," she said. "Intravenous administration of the vaccine strain also resulted in considerable slowing of tumor progression in the mice."

"Our study therefore proves the principle that the measles vaccine virus destroys lymphoma cells," says Dr. Fielding.

A pilot study is now underway at Mayo Clinic to test the use of the live measles vaccine virus in patients diagnosed with lymphoma. "If our laboratory findings translate to patients, then our research may lead to another treatment for patients who have failed current therapies for lymphoma and have exhausted their options for fighting the disease," says Dr. Fielding.

The two main types of lymphoma include Hodgkin’s disease and non-Hodgkin’s lymphoma, each having its own patterns of growth, spread and response to treatment. This year, an estimated 63,600 Americans will be diagnosed with lymphoma and about 27,600 patients will die of the cancer. Unlike several other cancers that appear to be declining in incidence rates, lymphoma is on the increase nationally, according to the National Cancer Institute.

Chemotherapy alone or in combination with radiation therapy is the standard treatment for lymphoma. High-dose chemotherapy with bone marrow transplantation is the treatment used for patients who relapse after standard treatment. If proved effective, the treatment derived from the measles vaccine virus could become another treatment option for patients with relapsed lymphoma.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Laboratory Study Shows Measles Vaccine May Offer Novel Approach For Treating Lymphoma." ScienceDaily. ScienceDaily, 12 June 2001. <www.sciencedaily.com/releases/2001/06/010611072804.htm>.
Mayo Clinic. (2001, June 12). Laboratory Study Shows Measles Vaccine May Offer Novel Approach For Treating Lymphoma. ScienceDaily. Retrieved January 24, 2015 from www.sciencedaily.com/releases/2001/06/010611072804.htm
Mayo Clinic. "Laboratory Study Shows Measles Vaccine May Offer Novel Approach For Treating Lymphoma." ScienceDaily. www.sciencedaily.com/releases/2001/06/010611072804.htm (accessed January 24, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 24, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
This Is What It's Like To Date A Med Student

This Is What It's Like To Date A Med Student

BuzzFeed (Jan. 23, 2015) Dating is now speed-dating... or studying. Video provided by BuzzFeed
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins