Featured Research

from universities, journals, and other organizations

Scientists Sequence Genome Of Major Periodontal Disease Bacterium

Date:
June 13, 2001
Source:
NIH/National Institute Of Dental And Craniofacial Research
Summary:
Scientists have sequenced the genome of Porphyromonas gingivalis, a bacterium believed to play a major role in adult periodontitis, or gum disease. It is the first oral disease-causing microbe to be completely sequenced.

June 12, 2001 -- Scientists have sequenced the genome of Porphyromonas gingivalis, a bacterium believed to play a major role in adult periodontitis, or gum disease. It is the first oral disease-causing microbe to be completely sequenced. The annotated P. gingivalis sequence will be posted on the Internet today, making it freely available to researchers worldwide.

The sequencing project, supported by the National Institute of Dental and Craniofacial Research (NIDCR), was carried out by scientists at The Institute for Genomic Research (TIGR) in Rockville, MD in collaboration with The Forsyth Institute in Boston, MA.

"P. gingivalis is one of the most intensely studied dental pathogens," said Dennis Mangan, Ph.D., chief of NIDCR's Infectious Diseases and Immunity Branch. "There is a large cadre of researchers out there ready to use the sequence data to identify the genetic mechanisms for the organism's virulence and to develop better approaches for preventing or eradicating periodontitis."

Periodontitis is a chronic infectious disease of the gums and underlying bony tissues. Untreated, it can destroy those tissues and result in tooth loss. By conservative estimate, more than 35 million Americans have periodontitis.

The mouth is teeming with bacteria, most of which do not cause disease. But when the largely gram-positive community of bacteria that normally live in the spaces between the gums and teeth are displaced by gram-negative anaerobic bacteria, periodontitis sets in. A small number of gram-negative species are associated with specific forms of periodontitis; P.gingivalis is the organism associated with chronic and severe adult periodontitis.

With the genetic blueprint for P. gingivalis in hand, dental researchers will be able to identify potential targets for periodontal vaccines and drug therapies. Currently the primary treatments for periodontitis are deep cleaning (scaling and root planing) and surgery.

The P. gingivalis sequence also provides the scientific community at large with information on an organism from a major group of bacteria not previously sequenced: the bacteroides group of gram-negative anaerobes. The sequence, which contains 2.3 million DNA base pairs, will be valuable for comparative genomics and for advancing researchers' understanding of bacterial diversity. It will also enhance scientists' ability to find new gene targets for antibiotics that work on gram-negative anaerobes. These bacteria are naturally resistant to some antibiotics, and are acquiring resistance to many others.

The version of the P. gingivalis genome released today is available on the Comprehensive Microbial Resource web site at http://www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl. The genome has been provisionally annotated, meaning that the products of most genes within the genome, including many responsible for virulence and growth, are listed. Later this month, the P. gingivalis genome will also be posted on a new Oral Pathogens Database being created by the Los Alamos National Laboratory with support from the NIDCR.

The P. gingivalis genome project was led by Dr. Robert Fleischmann at TIGR. Working with Dr. Fleischmann were Drs. Margaret Duncan and Floyd Dewhirst at The Forsyth Institute. Additional information on the P. gingivalis genome project can be found at http://www.pgingivalis.org.

The NIDCR is a component of the National Institutes of Health (NIH) in Bethesda, MD. The Institute is the nation's leading supporter of research on oral, dental, and craniofacial health. NIH is an agency of the U.S. Department of Health and Human Services.


Story Source:

The above story is based on materials provided by NIH/National Institute Of Dental And Craniofacial Research. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Dental And Craniofacial Research. "Scientists Sequence Genome Of Major Periodontal Disease Bacterium." ScienceDaily. ScienceDaily, 13 June 2001. <www.sciencedaily.com/releases/2001/06/010613072516.htm>.
NIH/National Institute Of Dental And Craniofacial Research. (2001, June 13). Scientists Sequence Genome Of Major Periodontal Disease Bacterium. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2001/06/010613072516.htm
NIH/National Institute Of Dental And Craniofacial Research. "Scientists Sequence Genome Of Major Periodontal Disease Bacterium." ScienceDaily. www.sciencedaily.com/releases/2001/06/010613072516.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins