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Genes Crucial In The Control Of Tuberculosis Found By Gladstone Researchers

Date:
July 6, 2001
Source:
University Of California - San Francisco
Summary:
Controlling a tuberculosis infection requires an interplay of a distinct set of genes and immune system cells. Researchers are showing for the first time that the absence of one of those genes, called CCR2, can have fatal consequences. Without CCR2, which encodes a receptor known to be important in the body's response to inflammation, containing a tuberculosis infection becomes impossible.

Controlling a tuberculosis infection requires an interplay of a distinct set of genes and immune system cells. Researchers are showing for the first time that the absence of one of those genes, called CCR2, can have fatal consequences. Without CCR2, which encodes a receptor known to be important in the body's response to inflammation, containing a tuberculosis infection becomes impossible. The study is a joint collaboration between the Gladstone Institute of Cardiovascular Disease and the UCSF Division of Infectious Diseases. When specific proteins bind to the receptor, a cascade of events ends in signaling a select group of immune system cells to gather at the site of TB infection. In mice that lacked the receptor, those cells did not come together. These mice quickly succumbed to the disease and died. At autopsy, the mice had 100 times more bacteria in their lungs than the normal mice that had the receptor.


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The above story is based on materials provided by University Of California - San Francisco. Note: Materials may be edited for content and length.


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University Of California - San Francisco. "Genes Crucial In The Control Of Tuberculosis Found By Gladstone Researchers." ScienceDaily. ScienceDaily, 6 July 2001. <www.sciencedaily.com/releases/2001/07/010704093108.htm>.
University Of California - San Francisco. (2001, July 6). Genes Crucial In The Control Of Tuberculosis Found By Gladstone Researchers. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2001/07/010704093108.htm
University Of California - San Francisco. "Genes Crucial In The Control Of Tuberculosis Found By Gladstone Researchers." ScienceDaily. www.sciencedaily.com/releases/2001/07/010704093108.htm (accessed April 19, 2014).

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