Featured Research

from universities, journals, and other organizations

New Antimalarial Drug Succeeds In First Animal Tests

Date:
September 10, 2001
Source:
The Johns Hopkins University
Summary:
Researchers at The Johns Hopkins University have designed a new drug for malaria that has easily passed the first stage of preclinical testing in mice and rats.

Researchers at The Johns Hopkins University have designed a new drug for malaria that has easily passed the first stage of preclinical testing in mice and rats.

Scientists will announce their successful results in Chicago on August 29, 2001, at the American Chemical Society's annual summer meeting. The results will also appear as an expedited article in the September 2001 issue of the Journal of Medicinal Chemistry.

"The new compound is known as a carboxyphenyl trioxane, and its therapeutic index, the measure of a drug's safety and efficacy in treating a disease, is very good," says Gary Posner, Scowe Professor of Chemistry in the Krieger School of Arts and Sciences at Johns Hopkins. "In addition, it's water soluble and therefore easy to administer orally and intravenously."

Annually, malaria infects 300 million to 500 million people and causes 1.5 million to 3 million deaths. It is primarily spread by mosquito bites. The most commonly fatal strain of the malaria parasite is showing considerable resistance to current treatments, making development of new drugs a priority.

Posner worked with Theresa Shapiro, professor of Clinical Pharmacology at the Johns Hopkins School of Medicine, and co-workers Michael Parker, Heung Bae Jeon, Mikhail Krasavin, and Ik-Hyeon Paik to synthesize and test antimalarial drugs in the laboratory. Posner and Shapiro are active in the organization of the new $100 million Malaria Research Institute at the university's Bloomberg School of Public Health.

Posner, who will present at a symposium in Chicago called "Advances in controlling parasitic diseases," says results from first-stage testing of the drug's effectiveness and toxicity in mice and rats compared favorably to results from another water-soluble candidate for malaria treatment. That other drug is under development at the U.S. Walter Reed Army Institute of Research.

"There are some aspects where the Army's compound is better, and some where ours is better, and we hope that by showing that our carboxyphenyl trioxane has comparable potential, we'll receive support for further animal testing of it," says Posner.

Both compounds trace their roots to the work of Chinese organic chemists who 30 years ago isolated the pharmacologically active component of the plant artemisia, historically used by the Chinese as an herbal remedy for malaria.

With support from the National Institutes of Health since 1994, Posner's group has explored the details of how the active component of the herbal remedy fights malaria. Their research and that of other laboratories showed that the malaria parasite's metabolism creates products that react chemically with a peroxide (oxygen to oxygen) bond in the anti-malaria compound, generating harmful compounds such as oxidizing agents and carbon-free radicals that kill the parasite.

"Knowing the mechanistic details of how this happens gave us the insights we needed for rational design of new treatments," says Posner, who used his skills in what he calls "molecular architecture" to design molecules with improved malaria-fighting characteristics. The new carboxyphenyl trioxane is the best to emerge so far from hundreds of candidate molecules Posner's group has designed and synthesized.

Future plans include having a manufacturer produce a kilogram of the carboxyphenyl trioxane, which is completely synthetic, under "good manufacturing practice" conditions for testing in larger animals and in humans.


Story Source:

The above story is based on materials provided by The Johns Hopkins University. Note: Materials may be edited for content and length.


Cite This Page:

The Johns Hopkins University. "New Antimalarial Drug Succeeds In First Animal Tests." ScienceDaily. ScienceDaily, 10 September 2001. <www.sciencedaily.com/releases/2001/09/010905074943.htm>.
The Johns Hopkins University. (2001, September 10). New Antimalarial Drug Succeeds In First Animal Tests. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2001/09/010905074943.htm
The Johns Hopkins University. "New Antimalarial Drug Succeeds In First Animal Tests." ScienceDaily. www.sciencedaily.com/releases/2001/09/010905074943.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins