Featured Research

from universities, journals, and other organizations

Mayo Clinic Study Shows Long-Term Use Of Antidepressant Helps Smokers Who Stop Avoid Relapse, Gain Less Weight

Date:
September 20, 2001
Source:
Mayo Clinic
Summary:
Smokers who stop smoking by taking the antidepressant bupropion (Zyban™) used to treat nicotine addiction are less likely to relapse if they use the medication for one year, according to a Mayo Clinic study published in the September 18 issue of Annals of Internal Medicine.

ROCHESTER, MINN. -- Smokers who stop smoking by taking the antidepressant bupropion (Zyban™) used to treat nicotine addiction are less likely to relapse if they use the medication for one year, according to a Mayo Clinic study published in the September 18 issue of Annals of Internal Medicine.

Despite treatment advances to help people stop smoking, 70 to 80 percent of smokers who stop relapse within six to 12 months. This is the first long-term, multi-center study to evaluate the use of the antidepressant bupropion to prevent relapse.

Centers involved in the study were Mayo Clinic in Rochester, Minn.; Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, Calif.; Brown University, Providence, R.I.; Oregon Health Sciences University, Portland, Ore.; and Massachusetts General Hospital, Boston, Mass.

How the study was done

In the study, 784 participants took bupropion to help them stop smoking. After seven weeks of bupropion treatment, 461 participants had successfully stopped. Half of that group continued with bupropion for a year, and the other half took a placebo.

At year’s end, 55 percent of the group continuing to take bupropion were abstinent vs. 42 percent in the placebo group.

"That’s a significant and encouraging difference," says J. Taylor Hays, M.D., associate medical director of the Mayo Clinic Nicotine Dependence Center and lead investigator in the study.

However, at the two-year follow-up, the abstinence rates were nearly the same for both groups, about 40 percent. "These results show that longer term use of bupropion can help prevent smoking relapse. But we don’t know yet how long people should take it to be most effective."

Another benefit: less weight gain

Researchers also found participants taking bupropion gained less weight than those on the placebo. Those individuals taking bupropion gained an average of seven pounds less compared with individuals on placebo at the end of one year of treatment. "Weight gain is a common concern for people trying to stop smoking," says Dr. Hays. "Bupropion seems to make weight management a little easier."

Bupropion, which has been on the market for many years, is the first non-nicotine medication that has been proven to be effective in treating nicotine addiction. It is believed to mimic some of the action of nicotine by increasing the brain chemicals dopamine and norepinephrine. It is normally used for seven to 12 weeks as part of treatment to stop smoking. For most people, there are few or minor side effects.

Dr. Hays says people who are trying to quit smoking should ask their physician about longer-term use of bupropion to help prevent relapse.

"Bupropion could be the difference that helps people stay smoke-free, especially for people at higher risk for relapse such as those who live with another smoker or have had several failed attempts at quitting," he says.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Study Shows Long-Term Use Of Antidepressant Helps Smokers Who Stop Avoid Relapse, Gain Less Weight." ScienceDaily. ScienceDaily, 20 September 2001. <www.sciencedaily.com/releases/2001/09/010919073553.htm>.
Mayo Clinic. (2001, September 20). Mayo Clinic Study Shows Long-Term Use Of Antidepressant Helps Smokers Who Stop Avoid Relapse, Gain Less Weight. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2001/09/010919073553.htm
Mayo Clinic. "Mayo Clinic Study Shows Long-Term Use Of Antidepressant Helps Smokers Who Stop Avoid Relapse, Gain Less Weight." ScienceDaily. www.sciencedaily.com/releases/2001/09/010919073553.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins