Featured Research

from universities, journals, and other organizations

Loss Of New Cell Growth Gene Linked To Certain Human Cancers

Date:
October 1, 2001
Source:
Massachusetts General Hospital
Summary:
Researchers at Massachusetts General Hospital (MGH) have found that the loss of a recently discovered gene involved in cell growth may play an important role in the progression of some human cancers. The gene, called Cables, was discovered by the MGH team last year, and the latest results are published in the October 1 issue of Cancer Research.

Researchers at Massachusetts General Hospital (MGH) have found that the loss of a recently discovered gene involved in cell growth may play an important role in the progression of some human cancers. The gene, called Cables, was discovered by the MGH team last year, and the latest results are published in the October 1 issue of Cancer Research.

Related Articles


"The Cables gene may be an important tumor suppressor gene located on chromosome 18," says principal investigator Lawrence Zukerberg, MD, of the MGH Department of Pathology. "People have known that a region of that chromosome is often missing in cancer cells, and they've been searching for cancer genes around that area for some time now."

Zukerberg and his colleagues found that the Cables gene is located on a chromosomal region that is frequently lost in colon, pancreatic, and squamous cancers. They also discovered that expression of the Cables protein is missing in these cancer cells. "We stained human tumor tissues such as colon and head and neck squamous cell carcinomas ? and found that 50 to 60 percent seem to be missing this protein," Zukerberg says.

The Cables protein normally acts to inhibit cell growth through a chain reaction effect. Cables prompts a protein called Wee1 to interact with another protein called cdk2, which plays a key role in encouraging cells to divide and grow. When it interacts with the Wee1 protein, however, cdk2's activity is diminished. So ultimately, expression of the Cables protein leads to decreased cell division.

Zukerberg's recent findings indicate that expression of the Cables protein may be important for thwarting the uncontrolled cell growth that is indicative of cancer. Without the protein, cells may be able to divide faster and could eventually become cancerous if they have a growth advantage over neighboring cells.

The next step for the MGH researchers is to try to prove that the Cables gene is a true tumor suppressor. They plan to knock out the gene in a mouse model to see if the effect leads to tumor development. They will also sequence the Cables gene from primary human tumor tissues to look for any potential mutations.

Other scientists involved in the study include Chin-Lee Wu, MD, PhD, Hua Xiao, MD, PhD, Daniel Chung, MD, Yenning Chuang, and Sandra Kirley. Laboratory support was provided by Scott McDougal, MD, Chief of Urology at MGH.

The Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $300 million and major research centers in AIDS, the neurosciences, cardiovascular research, cancer, cutaneous biology, photomedicine, transplantation biology. In 1994, the MGH joined with Brigham and Women's Hospital to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups and non acute and home health services.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Loss Of New Cell Growth Gene Linked To Certain Human Cancers." ScienceDaily. ScienceDaily, 1 October 2001. <www.sciencedaily.com/releases/2001/10/011001072058.htm>.
Massachusetts General Hospital. (2001, October 1). Loss Of New Cell Growth Gene Linked To Certain Human Cancers. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2001/10/011001072058.htm
Massachusetts General Hospital. "Loss Of New Cell Growth Gene Linked To Certain Human Cancers." ScienceDaily. www.sciencedaily.com/releases/2001/10/011001072058.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins