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Major Reduction In Cardiovascular Disease Seen In Mice Lacking CD44 Gene

Date:
October 2, 2001
Source:
Wistar Institute
Summary:
In a new study, when a strain of mice prone to atherosclerosis - cardiovascular disease - were specially bred to lack a gene called CD44, scientists saw reductions of up to 70 percent in the type of damage to blood-vessel walls associated with heart attacks and stroke. The reduction in disease is one of the greatest effects linked to a single gene yet reported in atherosclerosis. The significance of the observation is further underscored by the fact that CD44 represents a promising target for potential therapies.

PHILADELPHIA - In a new study, when a strain of mice prone to atherosclerosis - cardiovascular disease - were specially bred to lack a gene called CD44, scientists saw reductions of up to 70 percent in the type of damage to blood-vessel walls associated with heart attacks and stroke. The reduction in disease is one of the greatest effects linked to a single gene yet reported in atherosclerosis. The significance of the observation is further underscored by the fact that CD44 represents a promising target for potential therapies.


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The above story is based on materials provided by Wistar Institute. Note: Materials may be edited for content and length.


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Wistar Institute. "Major Reduction In Cardiovascular Disease Seen In Mice Lacking CD44 Gene." ScienceDaily. ScienceDaily, 2 October 2001. <www.sciencedaily.com/releases/2001/10/011002065345.htm>.
Wistar Institute. (2001, October 2). Major Reduction In Cardiovascular Disease Seen In Mice Lacking CD44 Gene. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2001/10/011002065345.htm
Wistar Institute. "Major Reduction In Cardiovascular Disease Seen In Mice Lacking CD44 Gene." ScienceDaily. www.sciencedaily.com/releases/2001/10/011002065345.htm (accessed April 17, 2014).

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