Featured Research

from universities, journals, and other organizations

Pattern In Protein Manufacture Found In Hippocampus

Date:
October 23, 2001
Source:
University Of Pennsylvania Medical Center
Summary:
Scientists at the University of Pennsylvania School of Medicine have discovered a pattern to protein manufacture in the hippocampus, the part of the brain devoted to making memories.

Scientists at the University of Pennsylvania School of Medicine have discovered a pattern to protein manufacture in the hippocampus, the part of the brain devoted to making memories.

Related Articles


Christy Job, PhD, a postdoctoral neurobiologist with James H. Eberwine, PhD, Professor of Pharmacology at Penn, measured a protein as it was being made in structures of brain cells called dendrites.

"The patterns of electrical stimulation which make memories are well-established, but how those memories are stored is still unexplained," said Job. "We decided to tackle this from a completely different angle by looking at protein synthesis in dendrites."

Job and Eberwine grew particular cells from the hippocampus called neurons that extend long structures (dendrites) away from the main portion of the cell, known as the cell body. Cell bodies store the genetic code (the DNA) so a message, mRNA, which is made from the DNA, moves from the cell body to dendrites.

Using a procedure known as multiphoton microscopy, Job and Eberwine were able to measure translation of this message into a protein that fluoresces. Multiphoton microscopy enabled them to examine the pattern of fluorescence across space and time.

"We thought that the rate of translation might be different in dendrites, but not only was it exponentially faster than translation in the cell body, it was also faster at particular places in each dendrite," Eberwine said.

The research, which will be published in the journal Proceedings of the National Academy of Science on October 23, could have important implications for other research into how memories are stored in the brain. Neuronal dendrites are known to pick up and convey information in the form of electrical pulses, but they could also store information by synthesizing proteins from mRNA templates.

"This raises the possibility that there is a pattern or code in the order of translation and mechanics of the translational process that exists in these translation sites at the dendritic level for the formation of memories," Eberwine said. "It could also be important for illnesses involving memory loss or mental retardation, such as Alzheimers and fragile X retardation."

The study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "Pattern In Protein Manufacture Found In Hippocampus." ScienceDaily. ScienceDaily, 23 October 2001. <www.sciencedaily.com/releases/2001/10/011023071849.htm>.
University Of Pennsylvania Medical Center. (2001, October 23). Pattern In Protein Manufacture Found In Hippocampus. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2001/10/011023071849.htm
University Of Pennsylvania Medical Center. "Pattern In Protein Manufacture Found In Hippocampus." ScienceDaily. www.sciencedaily.com/releases/2001/10/011023071849.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins