Featured Research

from universities, journals, and other organizations

Genetic Profiling May Play A Greater Role In Identifying Women At Risk From Breast Cancer

Date:
October 24, 2001
Source:
Federation Of European Cancer Societies
Summary:
A team of Cambridge University scientists has identified variants in six genes that may help to identify women at risk from breast cancer, ECCO 11 - the European Cancer Conference in Lisbon heard this week.

October 24, 2001 -- A team of Cambridge University scientists has identified variants in six genes that may help to identify women at risk from breast cancer, ECCO 11 - the European Cancer Conference in Lisbon heard today.

A strong family history, involving dominant genes, is already well established as a cause of breast cancer. Mutations in the so-called BRCA1 and 2 genes are estimated to account for about 15-20 per cent of familial breast cancer.

But the Cambridge research may lead to the development of further tests to identify women who are at risk from other genetic mutations. Professor Bruce Ponder, of the Cancer Research Campaign Department of Oncology at the university, said: "The number and type of genes that account for the remainder of familial breast cancer is not clear. It is, however, plausible, that at least some of this genetic predisposition is attributable to the effects of multiple, common, but individually weak genes".

Identifying such genes could help scientists to create "genotype profiles" to determine the risk of individual women at risk from the disease. These could be used in pre-symptomatic screening, diagnosis and treatment of the disease.

Professor Ponder believes that "genotype profiles" may ultimately prove to be more effective than "established clinical risk factors" in determining if an individual woman is at risk. These factors include age, reproductive factors including age of menarche (first period) and menopause, high-fat diet, alcohol consumption and high socio-economic status.

He explained: "These established risk factors are all very important, but they are not good discriminants of risk for the individual. It's been shown that if you take a series of ten thousand women and evaluate them according to these factors, you can predict fairly accurately how many of them will get breast cancer. But what you can't do is to tell which women will get it and which won't.

"We hope that the genetic profiles will be much more specific - and tell us which individuals are at high risk and which are not."

What is the next stage in the research? "This is a field which is at the very beginning. We now need our results to be replicated by two or three other groups."


Story Source:

The above story is based on materials provided by Federation Of European Cancer Societies. Note: Materials may be edited for content and length.


Cite This Page:

Federation Of European Cancer Societies. "Genetic Profiling May Play A Greater Role In Identifying Women At Risk From Breast Cancer." ScienceDaily. ScienceDaily, 24 October 2001. <www.sciencedaily.com/releases/2001/10/011024073000.htm>.
Federation Of European Cancer Societies. (2001, October 24). Genetic Profiling May Play A Greater Role In Identifying Women At Risk From Breast Cancer. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2001/10/011024073000.htm
Federation Of European Cancer Societies. "Genetic Profiling May Play A Greater Role In Identifying Women At Risk From Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2001/10/011024073000.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins