Featured Research

from universities, journals, and other organizations

T Cell Molecules May Play A Role In Ischemia

Date:
November 7, 2001
Source:
Johns Hopkins Medical Institutions
Summary:
Ischemia, or an interruption in blood flow to tissue, greatly decreases the success of transplanted kidneys. There's no specific treatment, partly because physicians don't know exactly how the injury occurs. But now, a new study shows that in mice, at least, tiny molecules within specialized immune system cells may hold some clues.

Ischemia, or an interruption in blood flow to tissue, greatly decreases the success of transplanted kidneys. There's no specific treatment, partly because physicians don't know exactly how the injury occurs. But now, a new study shows that in mice, at least, tiny molecules within specialized immune system cells may hold some clues.

Related Articles


Reporting in the current issue of The Journal of Clinical Investigation, a team led by Hamid Rabb, M.D., medical director of the kidney transplant program at Johns Hopkins, shows that during ischemia, one kind of these so-called T cells acts out of character.

The cells in question are CD4 cells, best known as the cells targeted by HIV. Also called helper T cells, they help identify, attack and destroy specific bacteria, fungi and other germs that infect the body by regulating the production of antibodies (proteins that fight infections) and cytokines (chemicals that regulate other immune functions).

During the study, researchers compared mice specially bred without CD4 cells to normal mice with induced ischemia and kidney failure, and found that the mice without CD4 cells were about 40 percent better protected from damage. When normal CD4 cells were reintroduced into the genetically altered mice, the amount of ischemic damage increased, further demonstrating that during ischemia, the CD4 cells somehow helped mediate the damage. Two CD4 cell molecules – CD28 and IFN-gamma – were identified as participating in the injury process.

"This challenges our ideas of what T cells do, and provides a novel avenue for developing therapies to minimize or reverse ischemic damage," Rabb says. "The exciting thing is we think this finding can apply to all areas of ischemia, including that caused by strokes and heart attacks."

Additional research will investigate the mechanism by which CD4 cells operate in ischemia, Rabb says.

The study was supported in part by the National Institutes of Health and the National Kidney Foundation. Other authors were Melissa J. Burne of Hopkins; Frank Daniels, Asmaa El Ghandour and Michael P. O'Donnell of Hennepin County Medical Center at the University of Minnesota, Minneapolis; and Shamila Mauiyyedi and Robert B. Colvin of Massachusetts General Hospital at Harvard Medical School, Boston.

Reference: Burne, M.J., et. al., "Identification of the CD4+ T cell as a major pathogenic factor in ischemic acute renal failure," The Journal of Clinical Investigation, Nov. 2001, Vol. 108, No. 9.

Related Web sites:

The Johns Hopkins Comprehensive Transplant Center http://www.hopkinsmedicine.org/transplant

The Journal of Clinical Investigation http://www.jci.org


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "T Cell Molecules May Play A Role In Ischemia." ScienceDaily. ScienceDaily, 7 November 2001. <www.sciencedaily.com/releases/2001/11/011107072514.htm>.
Johns Hopkins Medical Institutions. (2001, November 7). T Cell Molecules May Play A Role In Ischemia. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2001/11/011107072514.htm
Johns Hopkins Medical Institutions. "T Cell Molecules May Play A Role In Ischemia." ScienceDaily. www.sciencedaily.com/releases/2001/11/011107072514.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins