Featured Research

from universities, journals, and other organizations

Popular Arthritis Drug May Enhance Radiation Effects Against Cancer

Date:
November 8, 2001
Source:
Thomas Jefferson University
Summary:
Researchers at Jefferson Medical College have shown in the laboratory that a popular arthritis drug, Vioxx, may enhance the effects of radiation against cancer.

Researchers at Jefferson Medical College have shown in the laboratory that a popular arthritis drug, Vioxx, may enhance the effects of radiation against cancer.

Interest in such arthritis drugs, known as cox-2 inhibitors and which include the well known drug Celebrex, stems from the mechanism by which they apparently work against cancerous tumors. According to Adam Dicker, M.D., Ph.D., assistant professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and a member of Jefferson's Kimmel Cancer Center, who led the work, the drugs appear to affect angiogenesis, a process by which a tumor's growth is fed by the development of blood vessels. A new field of research on anti-cancer drugs known as angiogenesis inhibitors has sprung up in recent years based on the concept that by blocking the formation of blood vessels, cancers cannot grow or spread without a blood supply to feed them.

Dr. Dicker presents his team's findings November 7 at the American Society for Therapeutic Radiology and Oncology meeting in San Francisco.

According to Dr. Dicker, tumors actually make cox-2, an enzyme, and nearly every tumor "overexpresses," or makes too much of it. It is also present in blood vessels associated with the tumor, though the enzyme's precise role is uncertain.

In animal models, both Vioxx and Celebrex have shown anti-tumor properties, in some cases even shrinking tumors, possibly through an anti-angiogenic effect.

Other researchers have demonstrated in animal models that Celebrex enhances the effects of radiation on tumors. But little had been known, Dr. Dicker explains, about the effects of Vioxx. Dr. Dicker, using various laboratory tests and a number of different models for angiogenesis, showed the drug also enhances the effects of radiation on tumor cells by interfering with angiogenesis.

"People are excited about cox-2 inhibitors because they appear to lower toxicity for patients with arthritis," he says. "In addition, they also enhance radiotherapy effects and have anti-angiogenic activity."

Angiogenesis has become one of the hottest areas of cancer research. Some researchers believe that anti-angiogenesis drugs will expand the armamentarium of drugs that will halt cancer growth, with the disease becoming more a chronic illness patients can live with.

Dr. Dicker is leading a number of clinical trials looking at the use of these inhibitors for the treatment of cancer. At the same time, he chairs the Cox-2 Inhibitor Working Group at the Radiation Therapy Oncology Group, a federally funded cancer clinical trials organization that is conducting trials nationwide on the use of cox-2 and its role in cancer therapy.

"There will be a lot of research in this area - it's an exciting time," Dr. Dicker says.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Popular Arthritis Drug May Enhance Radiation Effects Against Cancer." ScienceDaily. ScienceDaily, 8 November 2001. <www.sciencedaily.com/releases/2001/11/011108064331.htm>.
Thomas Jefferson University. (2001, November 8). Popular Arthritis Drug May Enhance Radiation Effects Against Cancer. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2001/11/011108064331.htm
Thomas Jefferson University. "Popular Arthritis Drug May Enhance Radiation Effects Against Cancer." ScienceDaily. www.sciencedaily.com/releases/2001/11/011108064331.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins